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Chen et al. Screening of genetic loci

Table 4: Microsatellite loci scanning using BALB/C, The Herpes virus genus (Herpesviridae) is among the
DBA-2 and C57BL/6 inbred mice enveloped, linear, double-stranded DNA viruses that
Microsatellite Susceptible Tolerant widely exist in nature. Approximately 100 HSV species
loci BALB/C DBA-2 C57BL/6 have already been identified or partially identified.
D17MIT245.1 194 200 202 Among them, two HSV species, SV-1 and HSV-2, that
D17MIT143.2 112 112 112
D17MIT46 218 208 236 share 50% homology, have been closely associated
D17MIT146.1 166 166 166 with humans. According to statistics provided by the
D17MIT51.1 152 152 154
D17MIT10.1 155 149 155 WHO, approximately 70% of the total population
D17MIT180.1 139 139 137
D17MIT20.1 163 163 175 worldwide carries HSV antibodies and more than one-
D17MIT184 126 126 128 third suffers from recurrent HSV infection. Along with
D17MIT93.1 155 169 155
D17MIT39.1 86 86 104 its high prevalence rate, a variety of human diseases
D17MIT122.1 141 123 141 are closely related with HSV infection, including human
Microsatellite loci with difference were marked in bold
herpes labialis, herpes conjunctivitis, 20 herpes zoster
been reports suggesting that the genetic background encephalitis and other diseases causing great harm to

might play an important role. [1,6-8] The causative factors human health. HSV encephalitis is the most common,
for different responses to infection, the possible sporadic, viral encephalitis, accounting for 10-20%
ways of intervention, the revolutionary changes of of acute, viral, encephalitis and 60-80% of natural
infection prevention, and the control that resulted from mortality. Understanding the complex and specific
those changes have aroused great interest among characteristics of HSV infection-related diseases has
the scientific community. In this study, we analyzed been a scientifically and socially pressing need that has
the genetic background that contributes to the HSV led to overcoming the recent difficulties in diagnosis
infection susceptibility. and treatment.

Table 5: Bioinformatics of genes in microsatellite loci D17MIT51.1 region
Corresponding
No. Mouse genome Functions
human genes
1 Epididymal fat pad weight QTL 3 QTL
2 Subcutaneous fat pad weight QTL 4 QTL
3 Spleen weight QTL 9 QTL
4 Early growth adjusted QTL 2 QTL
5 Early growth QTL 5 QTL
6 Pulmonary adenoma susceptibility 12 QTL
7 Weight 6 weeks QTL 11 QTL
8 Weight 10 weeks QTL 12 QTL
9 DNA segment, Chr 17, Hunter 19
10 DNA segment, Chr 17, Hunter 20
11 DNA segment, Chr 17, Hunter 21
12 Down syndrome critical region gene 1-like 1 DSCR1L1
13 Fat pad 7 QTL
14 Mandibular morphogenesis 1 QTL
15 MSM lymphoma resistance 1 QTL
16 Bystin-like BYSL
17 DNA segment, Chr 17, ERATO Doi 191, expressed
18 DNA segment, Chr 17, ERATO Doi 763, expressed
17 Methylmalonyl-Coenzyme A mutase MUT
18 Neuroscience mutagenesis facility, 318
19 Cysteine-rich secretory protein 2 CRISP2
20 DNA segment, Chr 17, Tubingen 37
21 DNA segment, Chr 17, Tubingen 16
22 Ventral midbrain iron content 9 QTL
23 Soft tissue heal 11 QTL
24 DNA segment, Chr 17, Tubingen 37
25 Gastritis type A susceptibility locus 4 QTL
26 H2 (histocompatibility-2, MHC ) Complex/cluster/region
27 Histocompatibility 2, Q region Complex/cluster/region
28 Long bones 10 QTL
29 Lymphoma latency acceleration QTL
30 Leishmaniasis resistance 1 QTL
31 Locomotor activity 2 QTL
32 T cell receptor beta variable 4, control 1 QTL
33 T-cell receptor induced activation 3 QTL
34 Modifier of Odc1 QTL
35 UVB induced immunosuppression 2 QTL
36 Cleidocranial dysplasia Complex/cluster/region detail
37 Ectonucleotide Pyrophosphatase/phosphodiesterase 5 ENPP5
38 T-complex-associated testis expressed 1 TCTE1
39 Xenotropic murine leukemia virus 57
QTL: quantitative trait loci
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