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Liu et al. Neuroimmunol Neuroinflammation 2016;3:262-7 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.20
Neuroinflammation

www.nnjournal.net
Topic: Infectious Disease of Central Nervous System Open Access

Low antioxidant status of patients with

central nervous system infections

Jia Liu , Feng Tan , Min Li , Huan Yi , Li Xu , Xuan Wang , Xiu-Feng Zhong , Fu-Hua Peng 1
3
2*
1
1
1
1*
1
1 Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
2 Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, Guangdong, China.
3 Ophthalmology State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China.
*The first two authors contributed equally to this paper.
Correspondence to: Dr. Fu-Hua Peng, Department of Neurology, the Third Affiliated Hospital of Sun Yat-Sen University, Tian He Road No. 600,
Guangzhou 510630, Guangdong, China. E-mail: pfh93@163.com
How to cite this article: Liu J, Tan F, Li M, Yi H, Xu L, Wang X, Zhong XF, Peng FH. Low antioxidant status of patients with central nervous
system infections. Neuroimmunol Neuroinflammation 2016;3:262-7.
Dr. Jia Liu works in Department of Neurology, the Third Affiliated Hospital of Sun Yat-Sen University. Her main
research is the study of central nervous system infection and neuroimmunology.

ABSTRACT
Article history: Aim: The pathogenesis of central nervous system infections (CNSI) has not been fully
Received: 22-04-2016 understood; some studies indicated that reactive oxygen species may induce brain damage. The
Accepted: 01-09-2016 aim of our study was to investigate serum antioxidant status in patients with CNSI. Methods:
Published: 15-12-2016 The serum levels of uric acid (UA), bilirubin and albumin of 548 individuals were enrolled
in our study, comprising of 114 healthy controls (HC) and 434 patients with five different
Key words: kinds of CNSI, which including viral meningitis and/or meningoencephalitis, cysticercosis
Antioxidant, of brain, tuberculous meningitis and/or meningoencephalitis, cryptococcus meningitis and/or
uric acid, meningoencephalitis, and bacterial meningitis and/or meningoencephalitis. Results: The data
bilirubin, suggested that there were reducing levels of oxidation state (serum UA, bilirubin and albumin)
albumin, in CNSI patients when compared with HC. Likewise, similar results were observed when
central nervous system infection cohorts were divided into male and female subgroups. Conclusion: The authors demonstrated
that serum antioxidant status in patients with CNSI was lower; the reason may be due to
exhaustion of antioxidant capacity. Therefore, enhancing antioxidant power and keeping
oxidative stress and antioxidants in balance may be beneficial to the patients with CNSI.

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