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Chen. Neuroimmunol Neuroinflammation 2016;3:247-8 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.30
Neuroinflammation

www.nnjournal.net
Commentary Open Access

Comments on “Loss of intranetwork

and internetwork resting state functional

connections with Alzheimer’s disease

progression”

Jiu Chen

Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Correspondence to: Dr. Jiu Chen, Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87
DingJiaQiao Road, Nanjing, Jiangsu 210009, China. E-mail: ericcst@aliyun.com
How to cite this article: Chen J. Comments on “Loss of intranetwork and internetwork resting state functional connections with Alzheimer’s
disease progression”. Neuroimmunol Neuroinflammation 2016;3:247-8.
Article history: Received: 20-06-2016 Accepted: 27-06-2016 Published: 28-10-2016

Dr. Jiu Chen is a Ph.D. researcher with the background of neurology and clinical psychology. His research focus is
to investigate the pathogenesis of subjects at high risk to Alzheimer’s disease by using the multi-modal magnetic
resonance imaging (MRI) and event related potential (ERP) approaches.

Neuroimaging evidence of disconnection syndrome of of intra-network correlations in the DMN and other
Alzheimer’s disease (AD) is extremely fascinating. In networks at CDR 0.5. Second, they found increases
the study by Brier et al., they examined resting-state of intra-network correlations within the SAL between
[1]
functional-connectivity magnetic resonance imaging CDR 0 and CDR 0.5; however, they found reduced
(rs-fcMRI) in 5 functionally defined brain networks: intra-network correlations within all networks at CDR
default mode network (DMN), executive control network 1. Third, they found that the three network pairs, DMN-
(CON), salience network (SAL), dorsal attention DAN, DMN-SMN, and CON-SMN were preferentially
network (DAN), and sensory-motor network (SMN). affected at certain CDR stages. Finally, they found all
Within a large sample size of human participants of inter-network correlations consistently reduced with
either sex (n = 510), they divided subjects into three advancing CDR stage.
subgroups according to different AD severities, i.e.
unaffected (clinical dementia rating, CDR 0), very mild Therefore, the authors concluded from their study that
(CDR 0.5), and mild AD (CDR 1). The major findings AD is associated with widespread loss of both intra- and
of this study were as follows. First, they found a loss inter-network correlations; these findings suggested

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