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Agarwal et al. Neuroimmunol Neuroinflammation 2016;3:243-6 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.15
Neuroinflammation

www.nnjournal.net
Case Report Open Access

Cerebral venous thrombosis in patient of

relapse of ulcerative colitis: report of a

case

Rajat Agarwal, Anuradha Batra, Ish Anand, Davinder Singh Rana, Samir Patel

Department of Neurology, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi 110060, India.
Correspondence to: Dr. Rajat Agarwal, Department of Neurology, Sir Ganga Ram Hospital, 1st floor, Old building block, Old Rajinder Nagar, New
Delhi 110060, India. E-mail: dr.rajatagr@gmail.com

How to cite this article: Agarwal R, Batra A, Anand I, Rana DS, Patel S. Cerebral venous thrombosis in patient of relapse of ulcerative colitis:
report of a case. Neuroimmunol Neuroinflammation 2016;3:243-6.
ABSTRACT

Article history: Amongst the various systemic complications of ulcerative colitis, cerebral venous thrombosis
Received: 29-03-2016 (CVT) is an uncommon and serious neurological complication mainly associated during episodes
Accepted: 04-09-2016 of relapse of ulcerative colitis. CVT is suspected to be a consequence of hypercoagulable state
Published: 28-10-2016 occurring during the disease in genetic predisposed persons. Most patients present with rapid
neurological deterioration. This devastating intracranial complication requires immediate
Key words: medical intervention to avoid potentially life threatening consequences. The outcome is good,
Cerebral venous thrombosis, provided the disease is diagnosed on time and the treatment is started early. The authors present
ulcerative colitis relapse, a patient of CVT, a rare complication seen during relapse of ulcerative colitis.
inflammatory bowel disease,
extraintestinal complication

INTRODUCTION common thrombotic complications of UC are deep
venous thrombosis and pulmonary thromboembolism.
[3]
Ulcerative colitis is an idiopathic chronic inflammatory IBD accounts for 1-6% of the total causes of cerebral
bowel disease (IBD), which results from a complex venous thrombosis. The pathogenesis of CNS
relationship of environmental factors and genetic manifestations of IBD seems to be related to immune
predisposition. Ulcerative colitis (UC) is known to mechanisms or prothrombotic states; however the
[1]
have extra intestinal central nervous system (CNS) complete pathogenesis is yet to be elucidated. There
complications. CNS features in UC are particularly are no major differences in clinical or radiological
severe and rarely reported due to their varied characteristics, prognosis, or treatment between
presentation. These include cerebrovascular disease, patients of IBD-related cerebral venous thrombosis
myelopathy and cerebral vasculitis. The two most (CVT) and non-IBD related CVT. [4]
[2]
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