Page 213 - Read Online

Lira-Diaz et al. Neuroimmunol Neuroinflammation 2016;3:204-6 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.32
Neuroinflammation

www.nnjournal.net
Editorial Open Access

Emerging roles of microglia cells in the

regulation of adult neural stem cells

Eduardo Lira-Diaz , Oscar Gonzalez-Perez 1
1,2
1 Laboratory of Neuroscience, School of Psychology, University of Colima, Colima 28040, Mexico.
2 Medical Sciences PhD Program, School of Medicine, University of Colima, Colima 28040, Mexico.
Correspondence to: Dr. Oscar Gonzalez-Perez, Laboratory of Neuroscience, School of Psychology, University of Colima, Av. Universidad 333,
Colima 28040, Mexico. E-mail: osglez@ucol.mx
How to cite this article: Lira-Diaz E, Gonzalez-Perez O. Emerging roles of microglia cells in the regulation of adult neural stem cells.
Neuroimmunol Neuroinflammation 2016;3:204-6.
Article history: Received: 27-05-2016 Accepted: 17-08-2016 Published: 26-09-2016

Dr. Oscar Gonzalez-Perez is Professor of Neuroscience in the School of Psychology at the University of
Colima, Mexico (Research ID B-3680-2008, ORCID ID 0000-0002-6527-485X). He also is honorary professor
of Neuroscience in the Doctorado en Ciencias Biomedicas at the University of Guadalajara, Mexico, and an
invited professor of Neuroscience and Cellular Medicine in the Brain Tumor Stem Cell Laboratory of Dr. Alfredo
Quinones-Hinojosa at Johns Hopkins University School of Medicine. He is also member of several editorial
boards: Neuroimmunology and Neuroinflammation, Biomedical and Biological Reports, Journal of Neurology and
Epidemiology, American Journal of Stem Cells, and Clinical Immunology and Research.

MICROGLIA CELLS or cytokines. However, the immune response and
[1]
debris removing are not the only functions of microglial
Microglia cells are antigen presenting cells with myeloid cells. Recently, it has been identified that microglia
origin that constituted approximately 10% of all glial cells regulate neuronal apoptosis during the early
cells of the adult mouse brain. In the early embryo, brain development and modulate synaptic function.
[1]
the microglial precursors are located in the yolk sac and Strikingly, recent evidence indicates that microglia
progressively migrate throughout the primitive brain. cells can regulate neurogenesis in the adult brain.
[2]
In the adult brain, some of microglial cells derive from
the bone marrow, but this process only takes place THE VENTRICULAR-SUBVENTRICULAR
when the brain is lesioned. Microglial cells can display ZONE
[1]
4 morphological and functional stages: (1) resting
microglia; (2) active microglia; (3) phagocytic microglia; The adult mammalian brain possesses specialized
and (4) senescent microglia. One of the functions regions, also referred to as niches that host stem
[3]
of microglia is to provide the cell-mediated immunity cells with neurogenic potential. One of these niches
response against pathogens by releasing chemokines is the ventricular-subventricular zone (V-SVZ), an

Quick Response Code:
This is an open access article distributed under the terms of the Creative Commons Attribution-
NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work
non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

For reprints contact: service@oaepublish.com

204 © 2016 OAE Publishing Inc. www.oaepublish.com