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Mohan Interleukin-1beta: a common thread

rationale to further examine whether the management Chem 2001;276:43901-8.
of pain with opioids such as morphine contributes to a 16. O’Neill LA. Signal transduction pathways activated by the IL-1
receptor/toll-like receptor superfamily. Curr Top Microbiol Immunol
neuroinflammatory challenge that then leads to opioid 2002;270:47-61.
tolerance and other pain comorbidities. 17. Hibi M, Hirano T. Signal transduction through cytokine receptors. Int
Rev Immunol 1998;17:75-102.
Financial support and sponsorship 18. Kraus J, Borner C, Giannini E, Hollt V. The role of nuclear factor
kappaB in tumor necrosis factor-regulated transcription of the human
Supported by the Marshall University, School of mu-opioid receptor gene. Mol Pharmacol 2003;64:876-84.
Pharmacy, Faculty Research Support (FRS) grant. 19. Kraus J, Borner C, Lendeckel U, Hollt V. Interferon-gamma down-
regulates transcription of the mu-opioid receptor gene in neuronal and
immune cells. J Neuroimmunol 2006;181:13-8.
Conflict of interest 20. Kleibeuker W, Gabay E, Kavelaars A, Zijlstra J, Wolf G, Ziv N,
There are no conflicts of interest. Yirmiya R, Shavit Y, Tal M, Heijnen CJ. IL-1 beta signaling is
required for mechanical allodynia induced by nerve injury and for the
Patient consent ensuing reduction in spinal cord neuronal GRK2. Brain Behav Immun
2008;22:200-8.
No patient involved. 21. Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV,
Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D,
Ethics approval Zhang Y, Ellis AL, Yin HH, Campeau S, Rice KC, Roth BL, Maier
SF, Watkins LR. Morphine paradoxically prolongs neuropathic pain in
This article does not contain any studies with human rats by amplifying spinal NLRP3 inflammasome activation. Proc Natl
participants or animals. Acad Sci U S A 2016;113:E3441-50.
22. Nicotra L, Loram LC, Watkins LR, Hutchinson MR. Toll-like
receptors in chronic pain. Exp Neurol 2012;234:316-29.
REFERENCES 23. Peirs C, Seal RP. Targeting Toll-like receptors to treat chronic pain.
Nat Med 2015;21:1251-2.
1. Gaskin DJ, Richard P. The economic costs of pain in the United States. 24. Loram LC, Grace PM, Strand KA, Taylor FR, Ellis A, Berkelhammer D,
J Pain 2012;13:715-24. Bowlin M, Skarda B, Maier SF, Watkins LR. Prior exposure to repeated
2. Fletcher D, Martinez V. Opioid-induced hyperalgesia in patients morphine potentiates mechanical allodynia induced by peripheral
after surgery: a systematic review and a meta-analysis. Br J Anaesth inflammation and neuropathy. Brain Behav Immun 2012;26:1256-64.
2014;112:991-1004. 25. Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy
3. Carullo V, Fitz-James I, Delphin E. Opioid-induced hyperalgesia: a A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine
diagnostic dilemma. J Pain Palliat Care Pharmacother 2015;29:378-84. activates neuroinflammation in a manner parallel to endotoxin. Proc
4. Crofford LJ. Adverse effects of chronic opioid therapy for chronic Natl Acad Sci U S A 2012;109:6325-30.
musculoskeletal pain. Nat Rev Rheumatol 2010;6:191-7. 26. Jiang C, Xu L, Chen L, Han Y, Tang J, Yang Y, Zhang G, Liu W.
5. Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR. Selective suppression of microglial activation by paeoniflorin
Exploring the neuroimmunopharmacology of opioids: an integrative attenuates morphine tolerance. Eur J Pain 2015;19:908-19.
review of mechanisms of central immune signaling and their 27. Cai Y, Kong H, Pan YB, Jiang L, Pan XX, Hu L, Qian YN, Jiang
implications for opioid analgesia. Pharmacol Rev 2011;63:772-810. CY, Liu WT. Procyanidins alleviates morphine tolerance by
6. Drdla R, Gassner M, Gingl E, Sandkuhler J. Induction of synaptic long- inhibiting activation of NLRP3 inflammasome in microglia. J
term potentiation after opioid withdrawal. Science 2009;325:207-10. Neuroinflammation 2016;13:53.
7. Gruber-Schoffnegger D, Drdla-Schutting R, Honigsperger C, 28. Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith AL, Nakata T,
Wunderbaldinger G, Gassner M, Sandkuhler J. Induction of thermal Wu Z, Kohsaka S, Inoue K, Nakanishi H. BK channels in microglia
hyperalgesia and synaptic long-term potentiation in the spinal cord are required for morphine-induced hyperalgesia. Nat Commun
lamina I by TNF-alpha and IL-1beta is mediated by glial cells. J 2016;7:11697.
Neurosci 2013;33:6540-51. 29. Cui Y, Liao XX, Liu W, Guo RX, Wu ZZ, Zhao CM, Chen PX, Feng
8. Ferreira SH, Lorenzetti BB, Bristow AF, Poole S. Interleukin-1 beta JQ. A novel role of minocycline: attenuating morphine antinociceptive
as a potent hyperalgesic agent antagonized by a tripeptide analogue. tolerance by inhibition of p38 MAPK in the activated spinal microglia.
Nature 1988;334:698-700. Brain Behav Immun 2008;22:114-23.
9. Shavit Y, Wolf G, Goshen I, Livshits D, Yirmiya R. Interleukin-1 30. Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V,
antagonizes morphine analgesia and underlies morphine tolerance. Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L,
Pain 2005;115:50-9. Maier SF, Watkins LR. A role for proinflammatory cytokines and
10. Mohan S, Davis RL, DeSilva U, Stevens CW. Dual regulation of fractalkine in analgesia, tolerance, and subsequent pain facilitation
mu opioid receptors in SK-N-SH neuroblastoma cells by morphine induced by chronic intrathecal morphine. J Neurosci 2004;24:7353-65.
and interleukin-1beta: evidence for opioid-immune crosstalk. J 31. Johnson JL, Rolan PE, Johnson ME, Bobrovskaya L, Williams DB,
Neuroimmunol 2010;227:26-34. Johnson K, Tuke J, Hutchinson MR. Codeine-induced hyperalgesia
11. Ruzicka BB, Akil H. The interleukin-1beta-mediated regulation and allodynia: investigating the role of glial activation. Transl
of proenkephalin and opioid receptor messenger RNA in primary Psychiatry 2014;4:e482.
astrocyte-enriched cultures. Neuroscience 1997;79:517-24. 32. Raghavendra V, Rutkowski MD, DeLeo JA. The role of spinal
12. Vidal EL, Patel NA, Wu G, Fiala M, Chang SL. Interleukin-1 neuroimmune activation in morphine tolerance/hyperalgesia in
induces the expression of mu opioid receptors in endothelial cells. neuropathic and sham-operated rats. J Neurosci 2002;22:9980-9.
Immunopharmacology 1998;38:261-6. 33. Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier
13. Borner C, Hollt V, Kraus J. Involvement of activator protein-1 in SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-
transcriptional regulation of the human mu-opioid receptor gene. Mol glucuronide may cause pain enhancement via toll-like receptor 4/
Pharmacol 2002;61:800-5. MD-2 and interleukin-1beta. Neuroscience 2010;165:569-83.
14. Im HJ, Kang SW, Loh HH. Opioid receptor gene: cytokine response 34. Berta T, Liu T, Liu YC, Xu ZZ, Ji RR. Acute morphine activates
element and the effect of cytokines. Brain Res 1999;829:174-9. satellite glial cells and up-regulates IL-1beta in dorsal root ganglia in
15. Kraus J, Borner C, Giannini E, Hickfang K, Braun H, Mayer P, mice via matrix metalloprotease-9. Mol Pain 2012;8:18.
Hoehe MR, Ambrosch A, Konig W, Hollt V. Regulation of mu-opioid 35. Sanna MD, Ghelardini C, Galeotti N. Activation of JNK pathway in
receptor gene transcription by interleukin-4 and influence of an allelic spinal astrocytes contributes to acute ultra-low-dose morphine thermal
variation within a STAT6 transcription factor binding site. J Biol hyperalgesia. Pain 2015;156:1265-75.

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