Page 99 - Read Online
P. 99
7. Frösen J, Piippo A, Paetau A, Kangasniemi M, Niemelä M, 25. Morimoto M, Miyamoto S, Mizoguchi A, Kume N, Kita T,
Hernesniemi J, Jaaskelainen J. Remodeling of saccular cerebral Hashimoto N. Mouse model of cerebral aneurysm: experimental
artery aneurysm wall is associated with rupture: histological analysis induction by renal hypertension and local hemodynamic changes.
of 24 unruptured and 42 ruptured cases. Stroke 2004;35:2287‑93. Stroke 2002;33:1911‑5.
8. Jayaraman T, Berenstein V, Li X, Mayer J, Silane M, Shin YS, 26. Nuki Y, Tsou TL, Kurihara C, Kanematsu M, Kanematsu Y,
Niimi Y, Kilic T, Gunel M, Berenstein A. Tumor necrosis factor Hashimoto T. Elastase‑induced intracranial aneurysms in
alpha is a key modulator of inflammation in cerebral aneurysms. hypertensive mice. Hypertension 2009;54:1337‑44.
Neurosurgery 2005;57:558‑64. 27. Hosaka K, Downes DP, Nowicki KW, Hoh BL. Modified murine
9. Laaksamo E, Tulamo R, Liiman A, Baumann M, Friedlander RM, intracranial aneurysm model: aneurysm formation and rupture by
Hernesniemi J, Kangasniemi M, Niemela M, Laakso A, Frosen J. elastase and hypertension. J Neurointerv Surg 2014;6:474‑9.
Oxidative stress is associated with cell death, wall degradation, 28. Jou LD, Lee DH, Morsi H, Mawad ME. Wall shear stress on ruptured
and increased risk of rupture of the intracranial aneurysm wall. and unruptured intracranial aneurysms at the internal carotid artery.
Neurosurgery 2013;72:109‑17. AJNR Am J Neuroradiol 2008;29:1761‑7.
10. Tulamo R, Frösen J, Junnikkala S, Paetau A, Pitkäniemi J, 29. Takeuchi S, Karino T. Flow patterns and distributions of fluid velocity
Kangasniemi M, Niemela M, Jaaskelainen J, Jokitalo E, Karatas A, and wall shear stress in the human internal carotid and middle
Hernesniemi J, Meri S. Complement activation associates with cerebral arteries. World Neurosurg 2010;73:174‑85.
saccular cerebral artery aneurysm wall degeneration and rupture. 30. Shojima M, Oshima M, Takagi K, Torii R, Hayakawa M, Katada K,
Neurosurgery 2006;59:1069‑76. Morita A, Kirino T. Magnitude and role of wall shear stress on cerebral
11. Hasan D, Chalouhi N, Jabbour P, Hashimoto T. Macrophage aneurysm: computational fluid dynamic study of 20 middle cerebral
imbalance (M1 vs. M2) and upregulation of mast cells in wall artery aneurysms. Stroke 2004;35:2500‑5.
of ruptured human cerebral aneurysms: preliminary results. 31. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Egashira K, Hashimoto N.
J Neuroinflammation 2012;9:222. Impact of monocyte chemoattractant protein‑1 deficiency on
12. Laaksamo E, Tulamo R, Baumann M, Dashti R, Hernesniemi J, cerebral aneurysm formation. Stroke 2009;40:942‑51.
Juvela S, Niemela M, Laakso A. Involvement of mitogen‑activated 32. Aoki T, Kataoka H, Morimoto M, Nozaki K, Hashimoto N.
protein kinase signaling in growth and rupture of human intracranial Macrophage‑derived matrix metalloproteinase‑2 and ‑9 promote
aneurysms. Stroke 2008;39:886‑92. the progression of cerebral aneurysms in rats. Stroke 2007;38:162‑9.
13. Kataoka K, Taneda M, Asai T, Kinoshita A, Ito M, Kuroda R. 33. Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K,
Structural fragility and inflammatory response of ruptured cerebral Moriwaki T, Ishibashi R, Nozaki K, Morishita R, Hashimoto N.
aneurysms. A comparative study between ruptured and unruptured NF‑kappaB is a key mediator of cerebral aneurysm formation.
cerebral aneurysms. Stroke 1999;30:1396‑401. Circulation 2007;116:2830‑40.
14. Krischek B, Kasuya H, Tajima A, Akagawa H, Sasaki T, Yoneyama T, 34. Aoki T, Nishimura M, Matsuoka T, Yamamoto K, Furuyashiki T,
Ujiie H, Kubo O, Bonin M, Takakura K, Hori T, Inoue I. Network‑based Kataoka H, Kitaoka S, Ishibashi R, Ishibazawa A, Miyamoto S,
gene expression analysis of intracranial aneurysm tissue reveals role Morishita R, Ando J, Hashimoto N, Nozaki K, Narumiya S.
of antigen presenting cells. Neuroscience 2008;154:1398‑407. PGE(2) ‑EP(2) signalling in endothelium is activated by
15. Kurki MI, Häkkinen SK, Frösen J, Tulamo R, von und zu haemodynamic stress and induces cerebral aneurysm through an
Fraunberg M, Wong G, Tromp G, Niemela M, Hernesniemi J, amplifying loop via NF‑κB. Br J Pharmacol 2011;163:1237‑49.
Jaaskelainen JE, Yla‑Herttuala S. Upregulated signaling pathways 35. Kanematsu Y, Kanematsu M, Kurihara C, Tada Y, Tsou TL, van
in ruptured human saccular intracranial aneurysm wall: an Rooijen N, Lawton MT, Young WL, Liang EI, Nuki Y, Hashimoto T.
emerging regulative role of Toll‑like receptor signaling and nuclear Critical roles of macrophages in the formation of intracranial
factor‑kappaB, hypoxia‑inducible factor‑1A, and ETS transcription aneurysm. Stroke 2011;42:173‑8.
factors. Neurosurgery 2011;68:1667‑75. 36. Fukuda S, Hashimoto N, Naritomi H, Nagata I, Nozaki K, Kondo S,
16. Shi C, Awad IA, Jafari N, Lin S, Du P, Hage ZA, Shenkar R, Kurino M, Kikuchi H. Prevention of rat cerebral aneurysm
Getch CC, Bredel M, Batjer HH, Bendok BR. Genomics of human formation by inhibition of nitric oxide synthase. Circulation
intracranial aneurysm wall. Stroke 2009;40:1252‑61. 2000;101:2532‑8.
17. Li L, Yang X, Jiang F, Dusting GJ, Wu Z. Transcriptome‑wide 37. Aoki T, Fukuda M, Nishimura M, Nozaki K, Narumiya S. Critical role
characterization of gene expression associated with unruptured of TNF‑alpha‑TNFR1 signaling in intracranial aneurysm formation.
intracranial aneurysms. Eur Neurol 2009;62:330‑7. Acta Neuropathol Commun 2014;2:34.
18. Peters DG, Kassam AB, Feingold E, Heidrich‑O’Hare E, Yonas H, 38. Moriwaki T, Takagi Y, Sadamasa N, Aoki T, Nozaki K,
Ferrell RE, Brufsky A. Molecular anatomy of an intracranial Hashimoto N. Impaired progression of cerebral aneurysms in
aneurysm: coordinated expression of genes involved in wound interleukin‑1beta‑deficient mice. Stroke 2006;37:900‑5.
healing and tissue remodeling. Stroke 2001;32:1036‑42. 39. Sadamasa N, Nozaki K, Hashimoto N. Disruption of gene for
19. Inoue K, Mineharu Y, Inoue S, Yamada S, Matsuda F, Nozaki K, inducible nitric oxide synthase reduces progression of cerebral
Takenaka K, Hashimoto N, Koizumi A. Search on chromosome aneurysms. Stroke 2003;34:2980‑4.
17 centromere reveals TNFRSF13B as a susceptibility gene 40. Starke RM, Chalouhi N, Jabbour PM, Tjoumakaris SI, Gonzalez LF,
for intracranial aneurysm: a preliminary study. Circulation Rosenwasser RH, Wada K, Shimada K, Hasan DM, Greig NH,
2006;113:2002‑10. Owens GK, Dumont AS. Critical role of TNF‑α in cerebral aneurysm
20. Low SK, Zembutsu H, Takahashi A, Kamatani N, Cha PC, formation and progression to rupture. J Neuroinflammation
Hosono N, Kubo M, Matsuda K, Nakamura Y. Impact of LIMK1, 2014;11:77.
MMP2 and TNF‑α variations for intracranial aneurysm in Japanese 41. Yokoi T, Isono T, Saitoh M, Yoshimura Y, Nozaki K. Suppression of
population. J Hum Genet 2011;56:211‑6. cerebral aneurysm formation in rats by a tumor necrosis factor‑a
21. Ruigrok YM, Rinkel GJ, Wijmenga C. The versican gene and the inhibitor. J Neurosurg 2014;120:1193‑200.
risk of intracranial aneurysms. Stroke 2006;37:2372‑4. 42. Hayden MS, Ghosh S. NF‑kappaB, the first quarter‑century:
22. Kataoka H, Aoki T. Molecular basis for the development of remarkable progress and outstanding questions. Genes Dev
intracranial aneurysm. Expert Rev Neurother 2010;10:173‑87. 2012;26:203‑34.
23. Aoki T, Nishimura M. The development and the use of experimental 43. Aoki T, Nishimura M. Targeting chronic inflammation in cerebral
animal models to study the underlying mechanisms of CA formation. aneurysms: focusing on NF‑kappaB as a putative target of medical
J Biomed Biotechnol 2011;2011:535921. therapy. Expert Opin Ther Targets 2010;14:265‑73.
24. Hashimoto N, Handa H, Hazama F. Experimentally induced cerebral 44. Aoki T, Nishimura M, Kataoka H, Ishibashi R, Nozaki K,
aneurysms in rats. Surg Neurol 1978;10:3‑8. Hashimoto N. Reactive oxygen species modulate growth of cerebral
Neuroimmunol Neuroinflammation | Volume 2 | Issue 2 | April 15, 2015 91