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KPNA2 predicts long term survival in patients with anaplastic proinflammatory cytokine and IFN‑beta secretion in dendritic cells.
oligoastrocytomas. J Clin Neurosci 2014;21:1719‑24. J Immunol 2008;180:8020‑9.
16. Gousias K, Niehusmann P, Gielen GH, Simon M. Karyopherin 25. Almand B, Clark JI, Nikitina E, van Beynen J, English NR,
a2 and chromosome region maintenance protein 1 expression Knight SC, Carbone DP, Gabrilovich DI. Increased production
in meningiomas: novel biomarkers for recurrence and malignant of immature myeloid cells in cancer patients: a mechanism of
progression. J Neurooncol 2014;118:289‑96. immunosuppression in cancer. J Immunol 2001;166:678‑89.
17. Zheng M, Tang L, Huang L, Ding H, Liao WT, Zeng MS, Wang HY. 26. O’Doherty U, Steinman RM, Peng M, Cameron PU, Gezelter S,
Overexpression of karyopherin‑2 in epithelial ovarian cancer and Kopeloff I, Swiggard WJ, Pope M, Bhardwaj N. Dendritic cells
correlation with poor prognosis. Obstet Gynecol 2010;116:884‑91. freshly isolated from human blood express CD4 and mature
18. Dahl E, Kristiansen G, Gottlob K, Klaman I, Ebner E, Hinzmann B, into typical immunostimulatory dendritic cells after culture in
Hermann K, Pilarsky C, Durst M, Klinkhammer‑Schalke M, monocyte‑conditioned medium. J Exp Med 1993;178:1067‑76.
Blaszyk H, Knuechel R, Hartmann A, Rosenthal A, Wild PJ. 27. Martín‑Martín L, Almeida J, Hernández‑Campo PM, Sánchez ML,
Molecular profiling of laser‑microdissected matched tumor and Lécrevisse Q, Orfao A. Immunophenotypical, morphologic, and
normal breast tissue identifies karyopherin alpha2 as a potential functional characterization of maturation‑associated plasmacytoid
novel prognostic marker in breast cancer. Clin Cancer Res dendritic cell subsets in normal adult human bone marrow.
2006;12:3950‑60. Transfusion 2009;49:1692‑708.
19. Mortezavi A, Hermanns T, Seifert HH, Baumgartner MK, 28. Thomas R, Lipsky PE. Dendritic cells: origin and differentiation.
Provenzano M, Sulser T, Burger M, Montani M, Ikenberg K, Stem Cells 1996;14:196‑206.
Hofstadter F, Hartmann A, Jaggi R, Moch H, Kristiansen G, 29. Mikeska T, Bock C, El‑Maarri O, Hübner A, Ehrentraut D,
Wild PJ. KPNA2 expression is an independent adverse predictor Schramm J, Felsberg J, Kahl P, Buttner R, Pietsch T, Waha A.
of biochemical recurrence after radical prostatectomy. Clin Cancer Optimization of quantitative MGMT promoter methylation analysis
Res 2011;17:1111‑21. using pyrosequencing and combined bisulfite restriction analysis.
20. Winnepenninckx V, Lazar V, Michiels S, Dessen P, Stas M, Alonso SR, J Mol Diagn 2007;9:368‑81.
Avril MF, Ortiz Romero PL, Robert T, Balacescu O, Eggermont AM, 30. Pinzon‑Charry A, Maxwell T, Prato S, Furnival C, Schmidt C, López JA.
Lenoir G, Sarasin A, Tursz T, van den Oord JJ, Spatz A, Melanoma HLA‑DR+immature cells exhibit reduced antigen‑presenting
Group of the European Organization for R, Treatment of C. Gene cell function but respond to CD40 stimulation. Neoplasia
expression profiling of primary cutaneous melanoma and clinical 2005;7:1123‑32.
outcome. J Natl Cancer Inst 2006;98:472‑82. 31. Lind EF, Ahonen CL, Wasiuk A, Kosaka Y, Becher B, Bennett KA,
21. Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, Noelle RJ. Dendritic cells require the NF‑kappaB2 pathway for
Kros JM, Hainfellner JA, Mason W, Mariani L, Bromberg JE, Hau P, cross‑presentation of soluble antigens. J Immunol 2008;181:354‑63.
Mirimanoff RO, Cairncross JG, Janzer RC, Stupp R. MGMT gene 32. Fagerlund R, Melén K, Cao X, Julkunen I. NF‑kappaB p52, RelB
silencing and benefit from temozolomide in glioblastoma. N Engl J and c‑Rel are transported into the nucleus via a subset of importin
Med 2005;352:997‑1003. alpha molecules. Cell Signal 2008;20:1442‑51.
22. Hartmann C, Hentschel B, Wick W, Capper D, Felsberg J, 33. Chemnitz J, Turza N, Hauber I, Steinkasserer A, Hauber J. The
Simon M, Westphal M, Schackert G, Meyermann R, Pietsch T, karyopherin CRM1 is required for dendritic cell maturation.
Reifenberger G, Weller M, Loeffler M, von Deimling A. Patients with Immunobiology 2010;215:370‑9.
IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than
IDH1‑mutated glioblastomas, and IDH1 mutation status accounts
for the unfavorable prognostic effect of higher age: implications for Cite this article as: Gousias K, von Ruecker A, Gielen GH, Niehusmann P,
Waha A, Vatter H, Simon M. A potential role of karyopherin a2 in the impaired
classification of gliomas. Acta Neuropathol 2010;120:707‑18. maturation of dendritic cells observed in glioblastoma patients. Neuroimmunol
23. Tabatabai G, Stupp R, van den Bent MJ, Hegi ME, Tonn JC, Wick W, Neuroinflammation 2015;2(1):8-14.
Weller M. Molecular diagnostics of gliomas: the clinical perspective. Source of Support: Nil. Conflict of Interest: No.
Acta Neuropathol 2010;120:585‑92.
24. Cross JL, Kott K, Miletic T, Johnson P. CD45 regulates TLR‑induced Received: 20-08-2014; Accepted: 16-09-2014

14 Neuroimmunol Neuroinflammation | Volume 2 | Issue 1 | January 15, 2015