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In the present ongoing study, we determined and We presented the preliminary analysis of our ongoing
correlated DC subpopulations as well as expression of study on the immunity of patients with glioblastomas.
KPNA2 in patients with glioblastomas. Since KPNA2 Our first results comprise a limited studied population;
is thought to mediate the nuclear import of certain therefore, far reaching conclusions may not be drawn.
transcription factors, which may induce the maturation However, our data may be taken into consideration
of DCs, a certain correlation has been expected. Indeed, in order to design future larger relevant studies, in
our preliminary analysis suggests an association particular animal models with knock out techniques
between low KPNA2 nuclear expression and increased that may further clarify the role of importins in the
numbers of mature DCs. However, this correlation did maturation of DCs and in general in the immunological
not reach statistical significance so far (Fisher exact abnormalities observed in patients with glioblastomas.
test, P = 0.077) probably due to the limited studied
population. The observed inverse correlation between ACKNOWLEDGMENTS
KPNA2 expression and counts of mature DCs is not
surprising, since higher KPNA2 expression [14] and We thank Alexandra Breuer for her excellent assistance and
decreased counts of mature DCs have been both found technical support.
[4]
to characterize patients with malignant gliomas, The
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