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In summary, astrocytes are vital cell mediators for the 12. Meyer RP, Gehlhaus M, Knoth R, Volk B. Expression and function
cerebral homeostasis and play an important role in the of cytochrome p450 in brain drug metabolism. Curr Drug Metab
2007;8:297‑306.
pathophysiology and progression of a number of brain 13. Gonzalez‑Perez O, Gutierrez‑Fernandez F, Lopez‑Virgen V,
disorders. Every day, new evidence emerges to reveal Collas‑Aguilar J, Quinones‑Hinojosa A, Garcia‑Verdugo JM.
that the glial cells are much more than supporting Immunological regulation of neurogenic niches in the adult brain.
and nourishing cells in the brain. Thus, astrocytes are Neuroscience 2012;226:270‑81.
everything plus the glue. 14. Lo Vasco VR, Fabrizi C, Panetta B, Fumagalli L, Cocco L. Expression
pattern and sub‑cellular distribution of phosphoinositide specific
phospholipase C enzymes after treatment with U‑73122 in rat
ACKNOWLEDGMENTS astrocytoma cells. J Cell Biochem 2010;110:1005‑12.
15. Rivera‑Zengotita M, Yachnis AT. Gliosis versus glioma?: don’t grade
The National Institute of Health and the National until you know. Adv Anat Pathol 2012;19:239‑49.
Institute of Neurological Disorders and Stroke (NIH/ 16. Anderová M, Kubinová S, Mazel T, Chvátal A, Eliasson C, Pekny M,
Sykova E. Effect of elevated K(+), hypotonic stress, and cortical
NINDS; R01-NS070024), Consejo Nacional de Ciencia y spreading depression on astrocyte swelling in GFAP‑deficient mice.
Tecnologia (CONACyT; INFR2014-224359). Programa de Glia 2001;35:189‑203.
Desarrollo del Personal Docente (PRODEP-Redes 2014). 17. Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY,
Kim T, Lee J, Chun H, Park HJ, Lee da Y, Hong J, Kim HY, Oh SJ,
REFERENCES Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J,
Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ. GABA from reactive
astrocytes impairs memory in mouse models of Alzheimer’s disease.
1. Nye JS. The Notch proteins. Curr Biol 1999;9:R118. Nat Med 2014;20:886‑96.
2. Barker AJ, Ullian EM. New roles for astrocytes in developing synaptic 18. Tong CK, Alvarez‑Buylla A. SnapShot: adult neurogenesis in the
circuits. Commun Integr Biol 2008;1:207‑11. V‑SVZ. Neuron 2014;81:220‑220.e1.
3. Ota Y, Zanetti AT, Hallock RM. The role of astrocytes in the 19. Gonzalez‑Perez O, Alvarez‑Buylla A. Oligodendrogenesis in the
regulation of synaptic plasticity and memory formation. Neural Plast subventricular zone and the role of epidermal growth factor. Brain
2013;2013:185463. Res Rev 2011;67:147‑56.
4. Pekny M, Pekna M. Astrocyte reactivity and reactive astrogliosis: 20. Edgar N, Sibille E. A putative functional role for oligodendrocytes
costs and Benefits. Physiol Rev 2014;94:1077‑98. in mood regulation. Transl Psychiatry 2012;2:e109.
5. Barros LF. Metabolic signaling by lactate in the brain. Trends Neurosci 21. Seri B, García‑Verdugo JM, McEwen BS, Alvarez‑Buylla A.
2013;36:396‑404. Astrocytes give rise to new neurons in the adult mammalian
6. Halassa MM, Haydon PG. Integrated brain circuits: astrocytic hippocampus. J Neurosci 2001;21:7153‑60.
networks modulate neuronal activity and behavior. Annu Rev 22. Prochnow N, Abdulazim A, Kurtenbach S, Wildförster V,
Physiol 2010;72:335‑55. Dvoriantchikova G, Hanske J, Petrasch‑Parwez E, Shestopalov VI,
7. Seifert G, Steinhäuser C. Neuron‑astrocyte signaling and epilepsy. Dermietzel R, Manahan‑Vaughan D, Zoidl G. Pannexin1 stabilizes
Exp Neurol 2013;244:4‑10. synaptic plasticity and is needed for learning. PLoS One
8. Cabezas R, Avila M, Gonzalez J, El‑Bachá RS, Báez E, 2012;7:e51767.
García‑Segura LM, Jurado Coronel JC, Capani F, 23. Menn B, Garcia‑Verdugo JM, Yaschine C, Gonzalez‑Perez O,
Cardona‑Gomez GP, Barreto GE. Astrocytic modulation of blood Rowitch D, Alvarez‑Buylla A. Origin of oligodendrocytes in the
brain barrier: perspectives on Parkinson’s disease. Front Cell subventricular zone of the adult brain. J Neurosci 2006;26:7907‑18.
Neurosci 2014;8:211. 24. Deng Y, Xie D, Fang M, Zhu G, Chen C, Zeng H, Lu J,
9. Lundgaard I, Osório MJ, Kress BT, Sanggaard S, Nedergaard M. Charanjit K. Astrocyte‑derived proinflammatory cytokines induce
White matter astrocytes in health and disease. Neuroscience hypomyelination in the periventricular white matter in the hypoxic
2014;276:161‑73. neonatal brain. PLoS One 2014;9:e87420.
10. Kang K, Lee SW, Han JE, Choi JW, Song MR. The complex
morphology of reactive astrocytes controlled by fibroblast growth
factor signaling. Glia 2014;62:1328‑44. Cite this article as: Gonzalez-Perez O, Lopez-Virgen V,
11. Yao PS, Kang DZ, Lin RY, Ye B, Wang W, Ye ZC. Glutamate/ Quiñones-Hinojosa A. Astrocytes: everything but the glue. Neuroimmunol
Neuroinflammation 2015;2(2):115-7.
glutamine metabolism coupling between astrocytes and glioma cells:
neuroprotection and inhibition of glioma growth. Biochem Biophys Source of Support: Nil. Conflict of Interest: No.
Res Commun 2014;450:295‑9. Received: 15-09-2014; Accepted: 10-11-2014

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