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Cristina et al. Mini-invasive Surg 2017;1:186-90 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2017.22
www.misjournal.net
Case Report Open Access

Endovesical instillation of platelet rich

fibrin for treatment of interstitial cystitis:

case report of two patients

Falavolti Cristina , Maria Cristina Tirindelli , Antonella Nicotera , Tommasangelo Petitti , Giuseppe Avvisati ,
3
4
1
2
2
Maurizio Buscarini 5
1 Department of Urology, Villa Betania Hospital of Rome, Via Pio IV 42, 00165 Rome, Italy.
2 Department of Hematology, Campus Biomedico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy.
3 Department of General Surgery, University of Turin, Via Giuseppe Verdi 8, 10124 Turin, Italy.
4 Hygiene and Public Health, Campus Biomedico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy.
5 Department of Urology, Campus Biomedico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Correspondence to: Dr. Falavolti Cristina, Department of Urology, Villa Betania Hospital of Rome, Via Pio IV 42, 00165 Rome, Italy.
E-mail: c.falavolti@hotmail.com
How to cite this article: Cristina F, Tirindelli MC, Nicotera A, Petitti T, Avvisati G, Buscarini M. Endovesical instillation of platelet rich fibrin for treatment
of interstitial cystitis: case report of two patients. Mini-invasive Surg 2017;1:186-90.

ABSTRACT
Article history: Interstitial cystitis, also called painful bladder syndrome, is a chronic condition causing bladder
Received: 12 Jun 2017 pain and sometimes pelvic pain. The exact cause of interstitial cystitis is not known. Often, signs
First Decision: 4 Aug 2017 and symptoms are hard to elucidate and no single treatment works for everyone. We report two
Revised: 21 Aug 2017 cases of patients affected by interstitial cystitis treated with endovesical instillation of platelets
Accepted: 28 Sep 2017 rich fibrin (PRF). PRF is an autologous component that promotes angiogenesis, tissue growth
Published: 28 Dec 2017 and repair. This report presents the safety and the efficacy of PRF instillations in controlling
clinical symptoms and restoring quality of life.
Key words:
Bladder pain syndrome,
cystoscopy,
interstitial cystitis,
platelet rich fibrin

INTRODUCTION of bladder wall. The etiology causing the mucosal
damage is still unclear. The urothelium sustains
Benign diseases of bladder such as interstitial cystitis multiple injuries in contact with the acidic urine and
(IC) and complex hemorrhagic radiation-induced this leads to an increase in local nervous sensibility for
cystitis are highly disabling. IC is not a specific disease pain regulation. Patients are more sensitive to voiding
but represents a complex set of symptoms also called stimuli and suffer chronic pelvic pain, urgency and
“bladder pain syndrome”. This differs from common predisposition to urinary infections. These symptoms
bacterial cystitis as it is a non-infective bladder dramatically impact quality of life. Females are more
inflammation. IC is caused by cellular alteration affected than males. In 90% of cases, the patients are
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