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Crema et al.                                                                                                                                                         Minimally invasive esophagectomy in achalasia

           parasympathetic autonomic nervous system occurs    4.   Wang D, Zhang R, Sun K. The digestive functions of the stomach after
           in this condition (digestive tract myenteric and      esophagectomy with vagus nerve preserved or severed in esophageal
           submucosal plexuses). It is known that the chronically   cancer  patients:  a comparative  study.  Zhonghua Zhong Liu Za Zhi
                                                                 2000;22:414-6. (in Chinese)
           denervated stomach develops intrinsic mechanisms   5.   Eduardo C, Madureira AB, Lima VG, Castro AM, Silva AA, Junqueira
           that maintain motility and emptying. In patients with   IS. Microflora in chagasic megaesophagus. Rev Soc Bras Med Trop
           idiopathic megaesophagus undergoing vagotomy,         2002;35:39-42. (in Portuguese)
           impairment of gastric emptying is observed during   6.   Crema E, De Lima TS, Junqueira IS, Rodrigues Junior V, Terra Júnior
           the  first  months  after  surgery.  Previous  studies  have   JA, Silva  AA. Prevalence  study of esophageal  HPV infection  in
           shown better gastric emptying after esophagectomy     patients with megaesophagus and correlation with in situ and 24-hour
                                                                 PH measurement. Bras J Video-Sur 2010;3:181-5.
           even  in  patients  with  chagasic  megaesophagus  and   7.   Fonseca FM, Queiroz DM, Rocha AM, Prata A, Crema E, Rodrigues
           vagal nerve preservation.                             Junior V, Ramirez LE, Oliveira AG. Seroprevalence of Helicobacter
                                                                 pylori infection in chagasic and nonchagasic patients from the same
           With  a  standardized  multidisciplinary  protocol  and  a   geographical region of Brazil. Rev Soc Bras Med Trop 2012;45:194-8.
           team  adequately  trained  in  laparoscopy,  minimally   8.   DePaula  AL, Hashiba K, Ferreira EA, de Paula RA, Grecco E.
           invasive esophagectomy is an excellent option for the   Laparoscopic transhiatal esophagectomy with esophagogastroplasty.
                                                                 Surg Laparosc Endosc 1995;5:1-5.
           treatment of advanced megaesophagus. The technique   9.   Crema E, Ribeiro LB, Terra JA Jr, Silva AA. Laparoscopic transhiatal
           is easily standardized and reproducible, and provides   subtotal esophagectomy for the treatment of advanced megaesophagus.
           excellent postoperative outcomes.                     Ann Thorac Surg 2005;80:1196-201.
                                                              10.  Crema E, Ribeiro LB, Sousa RC, Terra Júnior JA, Silva BF, Silva AA,
           DECLARATIONS                                          Silva AV. Laparoscopic transhiatal esophagectomy for the treatment
                                                                 of advanced megaesophagus. An analysis of 60 cases. Rev Col Bras
                                                                 Cir 2009;36:118-22. (in Portuguese)
           Authors’ contributions                             11.  Crema  E, Cruvinel  LA, Werneck AM, de Oliveira  RM, Silva AA.
           Surgical procedures: E. Crema, J.A.T. Júnior, A.A. da   Manometric  and  radiologic  aspects  of Chagas' megaesophagus:
           Silva                                                 the  importance  to its surgical  treatment.  Rev  Soc Bras Med Trop
           Monitoring of patients: G.A. Terra, C.J. de Oliveira   2003;36:665-9. (in Portuguese)
           Teles                                              12.  Molena  D, Mungo B, Stem  M, Lidor  AO. Hospitalization  for
                                                                 esophageal  achalasia  in  the  United  States.  World J  Gastrointest
                                                                 Endosc 2015;7:1096-102.
           Financial support and sponsorship                  13.  Loviscek  MF,  Wright AS, Hinojosa MW, Petersen  R, Pajitnov  D,
           None.                                                 Oelschlager  BK, Pellegrini  CA. Recurrent  dysphagia  after  Heller
                                                                 myotomy:  is esophagectomy  always  the  answer?  J  Am Coll  Surg
                                                                 2013;216:736-43; discussion 743-4.
           Conflicts of interest                              14.  Orringer MB, Stirling MC. Esophageal resection for achalasia:
           There are no conflicts of interest.                   indications and results. Ann Thorac Surg 1989;47:340-5.
                                                              15.  Devaney EJ, Lannettoni  MD, Orringer MB, Marshall B.
           Patient consent                                       Esophagectomy  for achalasia:  patient  selection  and clinical
                                                                 experience. Ann Thorac Surg 2001;72:854-8.
           All patients were guided by the surgical technique and   16.  Rodgers M, Jobe BA, O'Rourke RW, Sheppard B, Diggs B, Hunter JG.
           the risks inherent in the procedure.                  Case volume as a predictor of inpatient mortality after esophagectomy.
                                                                 Arch Surg 2007;142:829-39.
           Ethics approval                                    17.  Patti MG, Molena D, Fisichella PM, Whang K, Yamada H, Perretta S,
           The procedure was approved by the Human Research      Way LW. Laparoscopic Heller myotomy and Dor fundoplication for
                                                                 achalasia: analysis of successes and failures. Arch Surg 2001;136:870-7.
           Ethics Committee of the Federal University of Triângulo   18.  Csendes A, Braghetto I, Burdiles P, Korn O, Csendes P, Henríquez
           Mineiro.                                              A. Very late results of esophagomyotomy for patients with achalasia:
                                                                 clinical, endoscopic, histologic, manometric, and acid reflux studies
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