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Ornaghi et al. Mini-invasive Surg 2021;5:42  https://dx.doi.org/10.20517/2574-1225.2021.50                                                                               Page 5 of 17



                                                                                                                                                                         LN yield was higher for RARC compared with
                                                                                                                                                                         ORC, with a median of 27 nodes (IQR 7-57)
                                                                                                                                                                         compared with 20.5 nodes (IQR 0-57) (P <
                                                                                                                                                                         0.001). The overall rate of N+ disease was low
                                                                                                                                                                         between both groups (P = 0.89)
                                                                                                                                                                         The overall complication rate was 75.4%, with
                                                                                                                                                                         no difference in rates between groups (76.3%
                                                                                                                                                                         vs. 73.9%, respectively, P = 0.83)
                                                                                                                                                                         The majority of complications (89.5% vs.
                                                                                                                                                                         82.3%) were < 3 CCS complications
                                                                                                                                                                         Overall 30- and 90-day readmission rates were
                                                                                                                                                                         24% and 29.8%, respectively, with no difference
                                                                                                                                                                         observed between ORC or RARC groups (P =
                                                                                                                                                                         0.67 and P = 0.68)
                                          [17]
                              Whittum et al.  ,   Retrospective   118           RARC            Median of 9  IC (106); others  Age, BMI, ASA score,   - Surgical: OT, type of UD,  17 patients (14%) showed a gynecological organ
                              2018              (monocentric                                    months (IQR  (12)           NAC, prior           EBL, ICU, LOS, 30- and 90- invasion at pathological specimen. These
                                                study)                                          6-13) for                   abdominal/pelvic     day complications, 30- and  patients had more LVI at TURBT (82% vs. 46%,
                                                                                                organ                       surgery, prior RT, LVI   90-day readmission;   P = 0.006), trigonal tumours at TURBT (59% vs.
                                                                                                invasion; 23                at TURBT, tumor site   - Pathological: pT stage   18%, P = 0.001), multifocal disease (65% vs.
                                                                                                months (IQR                 at TURBT, histology at  (gynecological organ   33%, P = 0.01), (71% vs. 22%, P < 0.001), PSMs
                                                                                                8-45) for no                TURBT                invasion), pN stage,    (24% vs. 4%; P = 0.02), and they less commonly
                                                                                                organ                                            histology, PSMs;        demonstrated pure urothelial carcinoma at
                                                                                                invasion                                         - Oncological: AC; 30- and  TURBT (18% vs. 66%, P < 0.001)
                                                                                                                                                 90-day OS               There was no statistically significant difference
                                                                                                                                                                         between the two groups in terms of hospital or
                                                                                                                                                                         ICU stay, complications, readmissions, mortality
                                                                                                                                                                         at 30 and 90 days
                                                                                                                                                                         On multivariate analysis, significant predictors of
                                                                                                                                                                         gynecological organ invasion were pN positive
                                                                                                                                                                         disease (OR 6.48, 95%CI: 1.64-25.51, P =
                                                                                                                                                                         0.008), trigonal tumour location (OR 5.72, 95%
                                                                                                                                                                         CI: 1.39-23.61, P = 0.02), and presence of variant
                                                                                                                                                                         histology (OR 18.52, 95%CI: 3.32-103.4, P =
                                                                                                                                                                         0.001)
                                        [22]
                              Tyritzis et al.  ,   Retrospective   70 (62 male, 8   RARC (nerve   Median of   iN            Age, sex, BMI, ASA   - Surgical: OT, type of   They recorded negative margins in 69 of 70
                              2013              (monocentric    female)         sparing-RARC in  30.3 months                score, preoperative   PLND, nerve sparing, EBL,  patients (98.6%). Clavien 3-5 complications
                                                study)                          all female)     (IQR 12.7-                  TNM, preoperative    LOS, ≥ 30-day/90-day    occurred in 22/70 patients (31.4%) at 30-day
                                                                                                35.6)                       grade, concomitant   complications according to  and 13/70 (18.6%) at > 30-day. At 90-day, the
                                                                                                                            CIS, NAC.            CCS;                    overall complication rate was 58.5%. Clavien < 3
                                                                                                                                                 - Pathological: pT stage,   and Clavien ≥ 3 complications were recorded in
                                                                                                                                                 pN stage, concomitant CIS,  15/70 patients (21.4%) and 26/70 (37.1%),
                                                                                                                                                 PSMs, GS, LN yield;     respectively
                                                                                                                                                 - Oncological: 24-month   Kaplan-Meier estimates for RFS, CSS and OS at
                                                                                                                                                 recurrence, recurrence   24 months were 80.7%, 88.9%, and 88.9%,
                                                                                                                                                 location, RFS, CCS, OS;   respectively
                                                                                                                                                 - Functional: 6/12-month   Daytime and nighttime continence at 12 months
                                                                                                                                                 daytime and nighttime   reaches 80%-90% in men and 70% women. At
                                                                                                                                                 continence (≤ 1 pad/die),   12 months, 46 men (74.2%) and 2 of 3 evaluable
                                                                                                                                                 6/12-month potency and   females (66.7%) were continent. One female
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