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Page 4 of 17 Ornaghi et al. Mini-invasive Surg 2021;5:42 https://dx.doi.org/10.20517/2574-1225.2021.50

Table 1. Overview of the studies investigating surgical and functional outcomes in female patients with bladder cancer treated with robot-assisted radical cystectomy, grouped by endpoints of
interest

Type of
Author, Type of Preoperative Peri- and Post-
year Study design Study size surgery Follow-up urinary variables operative outcomes Findings
diversion
[13]
Tuderti et al. , Retrospective 11 SS-RARC Median of iN Age, BMI, gender, ASA - Surgical: OT, Hb at Median OT was 255 min and the median LOS 7
2020 (monocentric 28 months score, preoperative discharge, LOS, days. Low-grade CCS complications occurred in
study) (IQR 14-51) eGFR, preoperative Hb, complications according to 4 patients (36.3%), while high-grade CCS not
NAC rate CCS; observed. 7 patients (63.7%) had an organ-
- Pathological: pT stage, confined disease at the pathologic specimen;
pN stage, histology, LN nodal involvement and PSMs not detected
yield, PSMs; No new onset of CKD stage 3b. After one year,
- Oncological: 1-year RFS, daytime and nighttime continence rates were
1-year CSS, 1-year OS; 90.9% and 86.4%, respectively. Three patients
- Functional: last eGFR, (27,2%) performed CIC twice a day
ONB stones, UES, need for QoL as well as physical and emotional
CIC; daytime and functioning (EORTC QLQ-C30) improved
nighttime continence, significantly over time (all P ≤ 0.04), while
recovery probabilities; urinary symptoms (EORTC QLQ-BLM30) and
EORTC QLQ-C30 and sexual function (FSFI) worsened at 3 months
EORTC QLQ-BLM30; FSFI with a significant recovery taking place at one
questionnaire year (all P ≤ 0.04)
Overall, 8 out of 11 patients (72.7%) were
sexually active at the 12-month evaluation
[18]
Narayan et al. , Retrospective 122 ORC (76), RARC NR ICUD (40/46 Age, race, BMI, - Surgical: OT; EBL, IT, PT, LOS (P = 0.13) was not statistically different
2019 (monocentric (46) RARC); ECUD smoking, NAC, ASA ICU, LOS, 30- and 90-day between the groups
study) score, CCI, prior pelvic complication rates OT was longer for RARC compared with ORC
surgery, preoperative according to CCS, 30- and [median 513 min (IQR 365-810) vs. 392 (IQR
TNM 90-day readmission rates; 208-875), respectively, P < 0.001]
- Pathological: pT stage, ORC women were significantly more likely to
pN stage, pM stage, LVI, require an IT: OR for ≥ 1 unit during ORC was
LN yield, PSMs 9.97 (95%CI: 3.39-29.31, P < 0.001) on
multivariable analysis. Nearly 68% of ORC
women received an IT, compared with only 24%
of RARC women. EBL was also significantly
greater in ORC group: median of 762 mL (IQR
600) compared to 275 mL (IQR 350 mL) among
RARC (P < 0.01). PT were not different between
the 2 groups (36% ORC vs. 26% RARC, P =
0.32). Considering IT and PT together, ORC
women were significantly more likely to have
undergone transfusion of ≥ 4 units compared to
RARC women with a OR 21.06 (95%CI: 6.51-
68.44, P < 0.001) on multivariable analysis
PSMs rate was low overall (4.9%), with no
statistically significant difference between the 2
techniques (4 for ORC and 2 for RARC)