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Page 4 of 17                                                                                Ornaghi et al. Mini-invasive Surg 2021;5:42  https://dx.doi.org/10.20517/2574-1225.2021.50


                             Table 1. Overview of the studies investigating surgical and functional outcomes in female patients with bladder cancer treated with robot-assisted radical cystectomy, grouped by endpoints of
                             interest

                                                                                                            Type of
                              Author,                                           Type of                                     Preoperative         Peri- and Post-
                              year              Study design    Study size      surgery         Follow-up   urinary         variables            operative outcomes      Findings
                                                                                                            diversion
                                        [13]
                              Tuderti et al.  ,   Retrospective   11            SS-RARC         Median of   iN              Age, BMI, gender, ASA  - Surgical: OT, Hb at   Median OT was 255 min and the median LOS 7
                              2020              (monocentric                                    28 months                   score, preoperative   discharge, LOS,        days. Low-grade CCS complications occurred in
                                                study)                                          (IQR 14-51)                 eGFR, preoperative Hb,  complications according to  4 patients (36.3%), while high-grade CCS not
                                                                                                                            NAC rate             CCS;                    observed. 7 patients (63.7%) had an organ-
                                                                                                                                                 - Pathological: pT stage,   confined disease at the pathologic specimen;
                                                                                                                                                 pN stage, histology, LN   nodal involvement and PSMs not detected
                                                                                                                                                 yield, PSMs;            No new onset of CKD stage 3b. After one year,
                                                                                                                                                 - Oncological: 1-year RFS,   daytime and nighttime continence rates were
                                                                                                                                                 1-year CSS, 1-year OS;   90.9% and 86.4%, respectively. Three patients
                                                                                                                                                 - Functional: last eGFR,   (27,2%) performed CIC twice a day
                                                                                                                                                 ONB stones, UES, need for  QoL as well as physical and emotional
                                                                                                                                                 CIC; daytime and        functioning (EORTC QLQ-C30) improved
                                                                                                                                                 nighttime continence,   significantly over time (all P ≤ 0.04), while
                                                                                                                                                 recovery probabilities;   urinary symptoms (EORTC QLQ-BLM30) and
                                                                                                                                                 EORTC QLQ-C30 and       sexual function (FSFI) worsened at 3 months
                                                                                                                                                 EORTC QLQ-BLM30; FSFI  with a significant recovery taking place at one
                                                                                                                                                 questionnaire           year (all P ≤ 0.04)
                                                                                                                                                                         Overall, 8 out of 11 patients (72.7%) were
                                                                                                                                                                         sexually active at the 12-month evaluation
                                         [18]
                              Narayan et al.  ,   Retrospective   122           ORC (76), RARC  NR          ICUD (40/46     Age, race, BMI,      - Surgical: OT; EBL, IT, PT,   LOS (P = 0.13) was not statistically different
                              2019              (monocentric                    (46)                        RARC); ECUD     smoking, NAC, ASA    ICU, LOS, 30- and 90-day   between the groups
                                                study)                                                                      score, CCI, prior pelvic  complication rates   OT was longer for RARC compared with ORC
                                                                                                                            surgery, preoperative   according to CCS, 30- and   [median 513 min (IQR 365-810) vs. 392 (IQR
                                                                                                                            TNM                  90-day readmission rates;   208-875), respectively, P < 0.001]
                                                                                                                                                 - Pathological: pT stage,   ORC women were significantly more likely to
                                                                                                                                                 pN stage, pM stage, LVI,   require an IT: OR for ≥ 1 unit during ORC was
                                                                                                                                                 LN yield, PSMs          9.97 (95%CI: 3.39-29.31, P < 0.001) on
                                                                                                                                                                         multivariable analysis. Nearly 68% of ORC
                                                                                                                                                                         women received an IT, compared with only 24%
                                                                                                                                                                         of RARC women. EBL was also significantly
                                                                                                                                                                         greater in ORC group: median of 762 mL (IQR
                                                                                                                                                                         600) compared to 275 mL (IQR 350 mL) among
                                                                                                                                                                         RARC (P < 0.01). PT were not different between
                                                                                                                                                                         the 2 groups (36% ORC vs. 26% RARC, P =
                                                                                                                                                                         0.32). Considering IT and PT together, ORC
                                                                                                                                                                         women were significantly more likely to have
                                                                                                                                                                         undergone transfusion of ≥ 4 units compared to
                                                                                                                                                                         RARC women with a OR 21.06 (95%CI: 6.51-
                                                                                                                                                                         68.44, P < 0.001) on multivariable analysis
                                                                                                                                                                         PSMs rate was low overall (4.9%), with no
                                                                                                                                                                         statistically significant difference between the 2
                                                                                                                                                                         techniques (4 for ORC and 2 for RARC)
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