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Figure 3. Forest plots for subgroup meta-analysis by patient source. The relationships between PD-1 overexpression and OS in Asia
patients (A) and in non-Asia patients (B) are shown. PD-1: programmed cell death protein 1; OS: overall survival; CI: confidence interval

Figure 4. Forest plots for subgroup meta-analysis stratified by cancer type. The relationships between PD-1 expression and OS in breast
cancer (A), ESCC (B) and ovarian cancer (C) are shown. PD-1: programmed cell death protein 1; OS: overall survival; ESCC: esophageal
squamous cell carcinoma; CI: confidence interval

significant difference between lymph node metastasis group (35.0%) and lymph node non-metastasis group
(21.4%) (OR = 2.55, 95% CI: 1.22-2.59, P = 0.01) [Figure 5A]; 3 studies reported the relationship of PD-1
2
overexpression with tumor grade. With no significant heterogeneity (P = 0.92, I = 0%), a fixed-effects model
was used in the study. The results revealed a significant difference between 274 grade 3/4 tissues (28.1%) and