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Page 8 of 11 Zhang et al. J Cancer Metastasis Treat 2018;4:16 I http://dx.doi.org/10.20517/2394-4722.2018.01

Figure 6. Begg’s funnel plot for publication bias analysis. HR: hazard ratio

Figure 7. Sensitivity analysis of the meta-analysis. CI: confidence interval

expressed by TILs with OS in solid tumor and revealed that the prognostic role of PD-1 by TILs is variant in
different solid tumor types. This study included 10 eligible publications with 12 cohort studies and a total of
1863 patients. To the best of our knowledge, this is the first systematic assessment of the association of PD-1
by TILs with OS in solid tumor.

With respect to the tumor type, when we performed the subgroup meta-analysis stratified by tumor types,
ovarian cancer was correlated with better survival for patients with high PD-1 levels rather than other
solid tumor. Although PD-1 by TILs was not associated with OS for all of included studies in the meta-
analysis [12,13,22-30] . However, the results of studies using different clone to PD-1 antibodies were controversy
in breast cancer [27,29] [Supplementary Figure 1] in our meta-analysis. One recent study reported the opposite
results using variant PD-L1 antibodies in melanoma and lung cancer . The difference of antibody clones,
[14]
limited specificity, or distinct IHC protocols used may be partly explain the contradictory results . Further
[31]
studies are urgent to clarify the impact of antibodies on the results of studies.