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Zhang et al. J Cancer Metastasis Treat 2018;4:16 Journal of Cancer
DOI: 10.20517/2394-4722.2018.01 Metastasis and Treatment

Meta-Analysis Open Access

The potential prognostic and predictive roles of
programmed cell death protein 1 expressed by

tumor-infiltrating lymphocytes in solid tumors:
a meta-analysis

Dong-Yun Zhang , Rong-Zhi Liu , Jian-Wei Ku , Yu-Hong Ma , Ying-Jie Yi 3
1
2
1
1
1 Department of Basic Medicine, Nanyang Medical College, Nanyang 473061, Henan, China.
2 Department of Medical Oncology, The Second Affiliated Hospital of Nanyang Medical College, Nanyang 473061, Henan, China.
3 Department of Book Cataloguing, Nanyang Medical College, Nanyang 473061, Henan, China.
Correspondence to: Dr. Dong-Yun Zhang, Department of Basic medicine, Nanyang Medical College, Nanyang 473061, Henan,
China. E-mail: zhangdy79@126.com
How to cite this article: Zhang DY, Liu RZ, Ku JW, Ma YH, Yi YJ. The potential prognostic and predictive roles of programmed
cell death protein 1 expressed by tumor-infiltrating lymphocytes in solid tumors: a meta-analysis. J Cancer Metastasis Treat
2018;4:16. http://dx.doi.org/10.20517/2394-4722.2018.01
Received: 2 Jan 2018 First Decision: 7 Feb 2018 Revised: 14 Feb 2018 Accepted: 28 Mar 2018 Published: 12 Apr 2018

Science Editors: Pravin D. Potdar, Shuen-Kuei Liao Copy Editor: Jun-Yao Li Production Editor: Cai-Hong Wang

Abstract
Aim: Several previous studies have evaluated the potential role of programmed cell death protein 1 (PD-1) expressed
by tumor-infiltrating lymphocytes (TILs) in various solid tumors and performed its prognosis role in patients’ survival
with inconsistent results. This study aims to further systematically evaluate the association of PD-1 by TILs with
clinicopathological parameters and clinical outcomes in solid tumor patients.

Methods: A comprehensive search was conducted in PubMed, Embase, Web of Science, CNKI and Wanfang databases
for relevant studies. The potential prognostic and predictive roles of PD-1 were assessed by pooled hazard ratio (HR),
odds ratio (OR) and 95% confidence intervals (CI). A total of 1863 patients were selected for in-depth analysis.

Results: The results demonstrated that PD-1 by TILs was correlated to overall survival for ovarian cancer (HR = 0.40,
95% CI: 0.26-0.61, P < 0.00001). Higher PD-1 expression was associated with lymph node metastasis (OR = 2.55,
95% CI: 1.22-5.29, P = 0.01) and tumor grade (OR = 3.08, 95% CI: 2.07-4.57, P < 0.00001).

Conclusion: The prognostic role of PD-1 by TILs is variant in different tumor types, which highlights the role of PD-1 by
TILs as a potential predictive and prognostic biomarker and the development of strategies against the PD-L1/PD-1 axis
would be a promising therapeutic target for some solid tumors.

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
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