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Page 6 of 13 Salas et al. J Cancer Metastasis Treat 2018;4:15 I http://dx.doi.org/10.20517/2394-4722.2017.66

Table 3. Relationship between clinicopathological features and neck recurrence (n = 78)
Neck recurrence (%)
No (n = 60) Yes (n = 18) P
Age (years), mean (range) 64.8 (21-89) 63.4 (31-80) 0.725
cT
T1-T2-T3 19 (31.7) 5 (27.8)
T4 41 (68.3) 13 (72.2) 0.754
N
N(-) 44 (73.3) 15 (83.3)
N(+) 16 (26.7) 3 (16.7) 0.536
Location
Upper alveolus 55 (91.7) 18 (100.0)
Hard palate 5 (8.3) 0 (0.0) -
Grade
Poor/moderate differentiation 30 (50.0) 4 (22.2)
Well differentiated 30 (50.0) 14 (77.8) 0.037
PNI
No 24 (61.5) 7 (53.8)
Yes 15 (38.5) 6 (46.2) 0.624
LVI
No 30 (75.0) 10 (76.9)
Yes 10 (25.0) 3 (23.1) 1.000
Tobacco
No 52 (86.7) 18 (100.0)
Yes 8 (13.3) 0 (0.0) -
Alcohol
No 56 (93.3) 17 (94.4)
Yes 4 (6.7) 1 (5.6) 1.000
P16
Negative 25 (89.3) 13 (100.0)
Positive 3 (10.7) 0 (0.0) -
PNI: perineural invasion; LVI: lymphovascular infiltration

A B

C D

Figure 1. P16 by immunohistochemistry in upper maxilla. (A, B, C) Positive status of p16 staining indicated
by brown staining of nuclear and cytoplasmic membrane in three cases; (D) negative status for p16
staining. (Magnification 40×)