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Page 4 of 13                               Salas et al. J Cancer Metastasis Treat 2018;4:15  I  http://dx.doi.org/10.20517/2394-4722.2017.66


                                                    Table 1. General features
                                                                          Cases             %
                        Age (years), mean (range)                        64.47 (21-89)
                        Gender
                          Female                                         43                55.1
                          Male                                           35                44.9
                        Tobacco
                          Yes                                            8                 10.3
                          No                                             70                89.7
                        Alcohol
                          Yes                                            5                 6.4
                          No                                             73                93.6
                        Location
                          Hard palate                                    5                 6.4
                          Upper alveolus                                 73                93.6
                        cT
                          T2-T3                                          22                28.2
                          T4                                             54                69.2
                        cN
                          cN0                                            54                69.2
                          cN-positive                                    24                30.8
                        Clinical stage
                          I                                              1                 1.3
                          II                                             14                17.9
                          III                                            6                 7.7
                          IV                                             57                73.1
                        Histological grade
                          Poor/moderate differentiation                  34                43.6
                          Well differentiated                            44                56.4
                        Perineural infiltration
                          No                                             31                39.7
                          Yes                                            21                26.9
                        Lymphovascular invasion
                          No                                             40                51.3
                          Yes                                            13                16.7
                        p16
                          Negative                                       38                48.7
                          Positive                                       3                 3.8
                        Neck dissection
                          No                                             54                69.2
                          Yes                                            24                30.8
                        Time from initial surgery to neck recurrence (months), mean (range)  8.6 (2-29)
                        pN
                          N0                                             9                 11.5
                          N1                                             3                 3.8
                          N2                                             15                19.2
                          N3                                             1                 1.3
                          NX                                             50                64.1
                        Lymph node levels
                          I                                              9                 11.5
                          II                                             4                 5.1
                          I, II                                          5                 6.4
                          I, III                                         1                 1.3
                          II, III                                        1                 1.3
                          I, II, III                                     1                 1.3
                          II, V, contralateral                           1                 1.3
                          I, II, III, contralateral                      1                 1.3
                          I, II, III, IV, contralateral                  1                 1.3
                          Without registration data                      54                69.2
                        Extracapsular extension                          7                 29.2
                        N+ and N- with neck recurrence                   33                42.3
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