Page 183 - Read Online
P. 183

Liu et al.                                                                                                                                                                     Th17 activation by H. pylori and triglyceride

           differentiation and stabilization. [19,39]  In present study,   Ethics approval
           we note that significant amount of IL-6 and leptin are   Our  experimental  protocols were approved by  The
           seen in H. pylori-associated GC tissues, suggesting   Hospital Ethics Committee and The Ethics Committee
           that tumor microenvironment may be sufficient foster   of Xiamen University, China.
           Th17 development.
                                                              REFERENCES
           We finally demonstrate that RORγt, a transcriptional
           activator of IL-17A, [40,41]  is extensively induced in   1.   Khatoon J, Rai RP, Prasad KN. Role of Helicobacter pylori in gastric
           H. pylori-infected patients  [Figure 4C], and the     cancer: updates. World J Gastrointest Oncol 2016;8:147-58.
           expression  is further enhanced in advanced tumors   2.   Amieva M, Peek RM, Jr. Pathobiology of helicobacter pylori-induced
           [Figure 4E and F]. RORγt has been widely investigated   gastric cancer. Gastroenterology 2016;150:64-78.
           in Th17 cells but seldom in malignant diseases. Thus,   3.   O’Connor  A, O’Morain CA, Ford  AC. Population screening and
           future studies should include analysis of the important   treatment  of Helicobacter  pylori infection.  Nat Rev Gastroenterol
                                                                 Hepatol 2017;14:230-40.
           association of RORγt and H. pylori infection.      4.   de Martel C, Forman D, Plummer M. Gastric cancer: epidemiology
                                                                 and risk factors. Gastroenterol Clin North Am 2013;42:219-40.
           In summary, we demonstrate that H. pylori infection   5.   Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, Graham
           and abnormal lipid metabolism can exert a synergistic   DY.  Association  between  helicobacter  pylori  eradication  and
           role in Th17 activation and response to promote GC    gastric  cancer  incidence:  a  systematic review  and  meta-analysis.
           development.  These observations are important        Gastroenterology 2016;150:1113-24 e5.
           to understand GC pathogenesis and can be of        6.   Ford AC, Axon AT. Epidemiology of Helicobacter pylori infection and
           therapeutic significance.                             public health implications. Helicobacter 2010;15 Suppl 1:1-6.
                                                              7.   Wang F, Meng W, Wang B, Qiao L. Helicobacter pylori-induced gastric
                                                                 inflammation and gastric cancer. Cancer Lett 2014;345:196-202.
           DECLARATIONS                                       8.   Bornschein J, Kandulski A, Selgrad M, Malfertheiner P. From gastric
                                                                 inflammation to gastric cancer. Dig Dis 2010;28:609-14.
           Acknowledgments                                    9.   Hitzler I, Kohler E, Engler DB, Yazgan AS, Muller A. The role of Th
           We are grateful to all the patients who have contributed   cell subsets in the control of Helicobacter infections and in T cell-
           to the data of this work.                             driven gastric immunopathology. Front Immunol 2012;3:142.
                                                              10.  Ren Z, Pang G, Clancy R, Li LC, Lee CS, Batey R, Borody  T,
           Authors’ contributions                                Dunkley M. Shift of the gastric T-cell response in gastric carcinoma. J
                                                                 Gastroenterol Hepatol 2001;16:142-8.
           Conceived and designed the study: J.Z. Zeng, W. Han,   11.  Maruyama  T, Kono K, Mizukami  Y, Kawaguchi  Y, Mimura K,
           A.S.T. Wong, R.E. Ericksen                            Watanabe  M, Izawa S, Fujii  H. Distribution  of  Th17 cells  and
           Performed the study: H. Wang, G.  Chen, J. Liu, M.    FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-
           Yang, Z.X. Wu                                         draining lymph nodes and peripheral blood lymphocytes in patients
           Prepared the manuscript: J.Z. Zeng                    with gastric cancer. Cancer Sci 2010;101:1947-54.
           Revised the manuscript: W. Han, R.E. Ericksen      12.  Li B, Chen L, Sun H, Yang W, Hu J, He Y, Wei S, Zhao Z, Zhang J, Li
                                                                 H, Zou Q, Wu C. Immunodominant epitope-specific Th1 but not Th17
           Financial support and sponsorship                     responses mediate  protection  against  Helicobacter  pylori  infection
                                                                 following UreB vaccination of BALB/c mice. Sci Rep 2015;5:14793.
           This  work  is  supported by  grants from  the  10th   13.  Gray BM, Fontaine  CA, Poe SA, Eaton KA. Complex  T cell
           Singapore-China    Joint    Research    Program       interactions contribute to Helicobacter pylori gastritis in mice. Infect
           (S2014GR0448), Natural Science Foundation of China    Immun 2013;81:740-52.
           (NSFC) (81673467, 31471273, 21303145, 31340029,    14.  Serelli-Lee V, Ling KL, Ho C, Yeong LH, Lim GK, Ho B, Wong SB.
           30971445, 31501145), Research Grants Council (RGC)    Persistent Helicobacter pylori specific Th17 responses in patients with
           of Hong Kong Joint Research Scheme (NSFC/RGC)         past H. pylori infection are associated with elevated gastric mucosal
                                                                 IL-1beta. PLoS One 2012;7:e39199.
           (31461163002/N_HKU740/14  and  30931160431/N_      15.  Dixon BR, Radin JN, Piazuelo MB, Contreras DC, Algood HM. IL-
           HKU 735/09), Marine Drug Research Project of South    17a and IL-22 induce expression of antimicrobials in gastrointestinal
           Marine Center (14GYY023NF23), Fujian Province’s       epithelial cells and may contribute to epithelial cell defense against
           100-Talent Program of Innovation of Science and       Helicobacter pylori. PLoS One 2016;11:e0148514.
           Technology  (201510117), and the Fundamental       16.  Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, Huang
           Research  Funds for the Central Universities  (No.    E, Finlayson E, Simeone D, Welling TH, Chang A, Coukos G, Liu
           2013121037).                                          R, Zou  W. Phenotype, distribution, generation, and functional  and
                                                                 clinical relevance of Th17 cells in the human tumor environments.
                                                                 Blood 2009;114:1141-9.
           Conflicts of interest                              17.  Pinchuk IV, Morris KT, Nofchissey RA, Earley RB, Wu JY, Ma TY,
           There are no conflicts of interest.                   Beswick EJ. Stromal cells induce Th17 during Helicobacter  pylori
                                                                 infection  and  in  the  gastric  tumor  microenvironment.  PLoS One
           Patient consent                                       2013;8:e53798.
           Informed consents were signed by patients.         18.  Li J, Yue L, Wang H, Liu C, Liu H, Tao J, Qi W, Wang Y, Zhang W,
                           Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ August 29, 2017        175
   178   179   180   181   182   183   184   185   186   187   188