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Alotaibi et al. Papaya seeds effect prostate cancer

present in the black and white seeds to identify and Conflicts of interest
test the potential anticancer agent in black seeds of There are no conflicts of interest.
papaya.
Patient consent
In contrast to methanolic seeds extract from papaya Not applicable.
back seeds, we found that the aqueous extract of
papaya white seeds, surprisingly, stimulated prostate Ethics approval
cancer cell proliferation whereas aqueous extract Not applicable.
of black seeds has no effect. Papaya seeds are
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DECLARATIONS 14. Kenfield SA, Batista JL, Jahn JL, Downer MK, Van Blarigan EL,
Sesso HD, Giovannucci EL, Stampfer MJ, Chan JM. Development
Authors’ contributions and application of a lifestyle score for prevention of lethal prostate
cancer. J Natl Cancer Inst 2015;108: doi: 10.1093/jnci/djv329.
Performed the experiments: K.S. Alotaibi 15. Askari F, Parizi MK, Jessri M, Rashidkhani B. Fruit and vegetable
Analyzed the data: H. Li intake in relation to prostate cancer in Iranian men: a case-control
Cultivated papaya and contributed in the experimental study. Asian Pac J Cancer Prev 2014;15:5223-7.
design: R. Rafi 16. Aune D, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H,
Conceived and designed the study, and prepared the Acosta G, Mendilaharsu M. Fruits, vegetables, and the risk of cancer:
manuscript: R.A. Siddiqui a multisite case-control study in Uruguay. Asian Pac J Cancer Prev
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Agriculture Research Station, Virginia State University, 18. Hurst R, Hooper L, Norat T, Lau R, Aune D, Greenwood DC, e
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Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ August 28, 2017 167