Page 146 - Read Online

Sorrentino et al. Role of A 2B receptor in cancer

metastasis development. Int J Biochem Cell Biol 2006;38:544-62. in gastric cancer. Biochem Biophys Res Commun 2015;467:798-804.
97. Fang M, Xia J, Wu X, Kong H, Wang H, Xie W, Xu Y. Adenosine 113. Long JS, Schoonen PM, Graczyk D, O’Prey J, Ryan KM.
signaling inhibits CIITA-mediated MHC class II transactivation in p73 engages A2B receptor signalling to prime cancer cells to
lung fibroblast cells. Eur J Immunol 2013;43:2162-73. chemotherapy-induced death. Oncogene 2015;34:5152-62.
98. Xia J, Fang M, Wu X, Yang Y, Yu L, Xu H, Kong H, Tan Q, Wang H, 114. Hajiahmadi S, Panjehpour M, Aghaei M, Shabani M. Activation
Xie W, Xu Y. A2b adenosine signaling represses CIITA transcription of A2b adenosine receptor regulates ovarian cancer cell growth:
via an epigenetic mechanism in vascular smooth muscle cells. involvement of Bax/Bcl-2 and caspase-3. Biochem Cell Biol
Biochim Biophys Acta 2015;1849:665-76. 2015;93:321-9.
99. Ben Addi A, Lefort A, Hua X, Libert F, Communi D, Ledent C, 115. Daniele S, Zappelli E, Natali L, Martini C, Trincavelli ML.
Macours P, Tilley SL, Boeynaems JM, Robaye B. Modulation of Modulation of A1 and A2B adenosine receptor activity: a new
murine dendritic cell function by adenine nucleotides and adenosine: strategy to sensitise glioblastoma stem cells to chemotherapy. Cell
involvement of the A(2B) receptor. Eur J Immunol 2008;38:1610-20. Death Dis 2014;5:e1539.
100. Wilson JM, Ross WG, Agbai ON, Frazier R, Figler RA, Rieger 116. Desmet CJ, Gallenne T, Prieur A, Reyal F, Visser NL, Wittner BS,
J, Linden J, Ernst PB. The A2B adenosine receptor impairs the Smit MA, Geiger TR, Laoukili J, Iskit S, Rodenko B, Zwart W, Evers
maturation and immunogenicity of dendritic cells. J Immunol B, Horlings H, Ajouaou A, Zevenhoven J, van Vliet M, Ramaswamy
2009;182:4616-23. S, Wessels LF, Peeper DS. Identification of a pharmacologically
101. Xaus J, Valledor AF, Cardó M, Marquès L, Beleta J, Palacios JM, tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.
Celada A. Adenosine inhibits macrophage colony-stimulating factor- Proc Natl Acad Sci U S A 2013;110:5139-44.
dependent proliferation of macrophages through the induction of 117. Przybylski M. A review of the current research on the role of bFGF
p27kip-1 expression. J Immunol 1999;163:4140-9. and VEGF in angiogenesis. J Wound Care 2009;18:516-9.
102. Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn 118. Feoktistov I, Goldstein AE, Ryzhov S, Zeng D, Belardinelli L, Voyno-
MR, Biaggioni I, Dikov MM, Feoktistov I. Adenosinergic regulation Yasenetskaya T, Biaggioni I. Differential expression of adenosine
of the expansion and immunosuppressive activity of CD11b+Gr1+ receptors in human endothelial cells: role of A2B receptors in
cells. J Immunol 2011;187:6120-9. angiogenic factor regulation. Circ Res 2002;90:531-8.
103. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated 119. Feoktistov I, Ryzhov S, Zhong H, Goldstein AE, Matafonov A, Zeng
regulation of myeloid cells by tumours. Nat Rev Immunol D, Biaggioni I. Hypoxia modulates adenosine receptors in human
2012;12:253-68. endothelial and smooth muscle cells toward an A2B angiogenic
104. Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, Linden J. phenotype. Hypertension 2004;44:649-54.
Adenosine A2B receptor blockade slows growth of bladder and
breast tumors. J Immunol 2012;188:198-205. 120. Merighi S, Simioni C, Gessi S, Varani K, Mirandola P, Tabrizi MA,
105. Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Blockade of A2b Baraldi PG, Borea PA. A(2B) and A(3) adenosine receptors modulate
adenosine receptor reduces tumor growth and immune suppression vascular endothelial growth factor and interleukin-8 expression
mediated by myeloid-derived suppressor cells in a mouse model of in human melanoma cells treated with etoposide and doxorubicin.
melanoma. Neoplasia 2013;15:1400-9. Neoplasia 2009;11:1064-73.
106. Morello S, Miele L. Targeting the adenosine A2b receptor in the 121. Zeng D, Maa T, Wang U, Feoktistov I, Biaggioni I, Belardinelli L.
tumor microenvironment overcomes local immunosuppression by Expression and function of A 2B adenosine receptors in the U87MG
myeloid-derived suppressor cells. Oncoimmunology 2014;3:e27989. tumor cells. Drug Develop Res 2003;58:405-11.
107. Wei Q, Costanzi S, Balasubramanian R, Gao ZG, Jacobson KA. A2B 122. Sorrentino C, Miele L, Porta A, Pinto A, Morello S. Myeloid-derived
adenosine receptor blockade inhibits growth of prostate cancer cells. suppressor cells contribute to A2B adenosine receptor-induced
Purinergic Signal 2013;9:271-80. VEGF production and angiogenesis in a mouse melanoma model.
108. Vecchio EA, Tan CY, Gregory KJ, Christopoulos A, White PJ, May Oncotarget 2015;6:27478-89.
LT. Ligand-independent adenosine A2B receptor constitutive activity 123. Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid
as a promoter of prostate cancer cell proliferation. J Pharmacol Exp cells in the promotion of tumour angiogenesis. Nat Rev Cancer
Ther 2016;357:36-44. 2008;8:618-31.
109. Kasama H, Sakamoto Y, Kasamatsu A, Okamoto A, Koyama T, 124. Allard B, Turcotte M, Spring K, Pommey S, Royal I, Stagg J.
Minakawa Y, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. Anti-CD73 therapy impairs tumor angiogenesis. Int J Cancer
Adenosine A2b receptor promotes progression of human oral cancer. 2014;134:1466-73.
BMC Cancer 2015;15:563. 125. Sorrentino C, Miele L, Porta A, Pinto A, Morello S. Activation of
110. Gessi S, Merighi S, Varani K, Cattabriga E, Benini A, Mirandola P, the A2B adenosine receptor in B16 melanomas induces CXCL12
Leung E, Mac Lennan S, Feo C, Baraldi S, Borea PA. Adenosine expression in FAP-positive tumor stromal cells, enhancing tumor
receptors in colon carcinoma tissues and colon tumoral cell lines: progression. Oncotarget 2016;7:64274-88.
focus on the A(3) adenosine subtype. J Cell Physiol 2007;211:826-36. 126. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay
111. Ma DF, Kondo T, Nakazawa T, Niu DF, Mochizuki K, Kawasaki T, Naeem R, Carey VJ, Richardson AL, Weinberg RA. Stromal
T, Yamane T, Katoh R. Hypoxia-inducible adenosine A2B receptor fibroblasts present in invasive human breast carcinomas promote
modulates proliferation of colon carcinoma cells. Hum Pathol tumor growth and angiogenesis through elevated SDF-1/CXCL12
2010;41:1550-7. secretion. Cell 2005;121:335-48.
112. Wang P, Guo X, Zong W, Song B, Liu G, He S. MicroRNA-128b 127. Öhlund D, Elyada E, Tuveson D. Fibroblast heterogeneity in the
suppresses tumor growth and promotes apoptosis by targeting A2bR cancer wound. J Exp Med 2014;211:1503-23.

138 Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ July 17, 2017