Page 35 - Read Online

Hassan et al. Hepatoma Res 2017;3:27-33 Hepatoma Research
DOI: 10.20517/2394-5079.2016.33
www.hrjournal.net
Original Article Open Access

Antioxidant activity and free radical-scavenging

of cape gooseberry (Physalis peruviana L.) in

hepatocellular carcinoma rats model

Hanaa A. Hassan , Nermin E. Ghareb , Ghassan F. Azhari
1
1
2
1 Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
2 Ministry of Health, Makkah Region, Makkah 21514, Saudi Arabia.
Correspondence to: Prof. Hanaa A. Hassan, Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura 35516,
Egypt. E-mail: drhanaahassan@yahoo.com

How to cite this article: Hassan HA, Gharib NE, Azhari GF. Antioxidant activity and free radical-scavenging of cape gooseberry (Physalis peruviana L.)
in diethylnitrosamine-induced hepatocellular carcinoma. Hepatoma Res 2017;3:27-33.

Prof. Hanaa A. Hassan is a professor of Experimental Physiology and Ecology, Zoology Department,
Faculty of Science, Mansoura University. Dr. Hanaa held a position of professor at Institute of Animal
Physiology and head of Zoology Department during 2012-2015, Faculty of Science, Mansoura University.
She is interested in experimental nutritional therapy. Her current researches activities focus on evaluating
the role of traditional plants in modulating the carcinogenic effects and controlling diseases. She is
member of the editorial board of some peer-reviewed journals. Along her career, she published more than
60 articles in peer-reviewed journals. She chaired in funded project in the field of natural antioxidants as
a good factor for minimizing the risk factors of pollutants in Dakhalia, Mansoura, Egypt. She supervises
on more than 20 Msc and PhD thesis and is invited as examiners for a lot of thesis. Also she is a reviewer
in the committee of promotion for professors and assistance professors. She got many scientific prizes
(MSc Prize 1990, University Prize 2009 and Ideal Mother for students 2012). She got a nomination to
Who’s Who in Medicine and Healthcare 2011 Committee. Her current research activities deals with the
evaluation of some dietary natural antioxidants as replacement therapy to try the treatment of some common diseases such as diabetes,
atherosclerisis, Alzheimer’s, hepatocellular carcinoma, and breast cancer through experimental models.

ABSTRACT
Article history: Aim: Oxidative damage of cellular components by free radicals and other reactive oxygen
Received: 20-08-2016 molecules is believed to be associated with the development of degenerative diseases. The aim
Accepted: 07-12-2016 of the present study was to evaluate the antioxidant capacity and free radical scavenging activity
Published: 28-02-2017 of cape gooseberry juice (CGJ) in diethylnitrosamine-(DENA) and CCl (3 mL/kg b.w.)-induced
4
hepatocellular carcinoma (HCC) rats model. Methods: The rats were divided into 4 groups (6
Key words: rats each group). Group 1 (control): the rats of this group did not receive any treatments; group
Oxidative stress, 2 (CGJ): rats were daily administered cape gooseberry juice at a dose of 1 mL/kg b.w.; group 3
antioxidants, (HCC): the rats treated with a single intraperitoneal injection of fresh DENA (200 mg/kg body
cape gooseberry, weight) and received a subcutaneous injection of CCl (3 mL/kg/week); group 4: (HCC + CGJ):
4
diethylnitrosamine rats were treated with DENA (200 mg/kg b.w.) and CCl (3 mL/kg b.w. per week) in addition
4
to daily administered cape gooseberry juice at a dose of 1 mL/kg b.w. Results: Treatment
Quick Response Code:
This is an open access article distributed under the terms of the Creative Commons Attribution-
NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work
non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

For reprints contact: service@oaepublish.com

© 2017 OAE Publishing Inc. www.oaepublish.com 27