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Castán et al.                                                                                                                                           Radiology of hepatocarcinoma in non-cirrhotic patients

            A                                B                                C
















           Figure 15: Magnetic resonance imaging in axial planes with T1 sequences in noncontrast phase (A), and arterial contrast phase (B), and
           portal phase (C). Multiple lesions (yellow arrows) scattered in right hepatic lobe, hypointense in noncontrast phase (A) and uptake in early
           arterial phase (B), held in portal phase (C) corresponding to liver metastases of pancreatic neuroendocrine tumor
           (25%),  or  predominantly  cystic  (15%).  It  shows   and laboratory data suggesting a history of cirrhosis,
           peripheral enhancement in the arterial phase. In MRI it   biopsy  should  be  performed  in  all  lesions  with
           is hypointense on T1 and hyperintense on T2 and with   pathognomonic characteristics of HCC.
           an enhancement after administration of gadolinium
           similar to that obtained in CT.                    Financial support and sponsorship
                                                              None.
           In addition to the metastatic neuroendocrine tumors,
           other tumors with hypervascular appearance such    Conflicts of interest
           as  thyroid  tumors,  renal  tumors  or  melanomas,   There are no conflicts of interest.
           may  present  as  an  initial  liver  finding.  Such
           lesions are generally multiple and small, unlike the   Patient consent
           usual presentation of HCC. The uptake curve of
           hypervascular metastases is typical: very intense and   There is no patient involved.
           early enhancement in the arterial phase and also very
           early wash-out in the portal and equilibrium phases.   Ethics approval
           This dynamic behavior is similar to that presented in   This review paper is waived for ethics approval.
           HCC and therefore, if a primary tumor is not known
           and there is a small number of lesions, biopsy is   REFERENCES
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