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Figure 1: CK8/18 expression in hepatocellular carcinoma (a; case 1, c; case 2, e; control) and background liver (b; case1, d; case 2, f; control),
demonstrated with mouse monoclonal antibodies B22.1/B23.1 (Cell Marque, USA) and visualized using the Envision method (Dako)
(a-f, ×400). Control (a 79-year-old male, moderately differentiated adenocarcinoma in background of nearly normal liver)
Financial support and sponsorship 2016;2:26-30.
Nil. 2. Bannasch P, Klimek F, Mayer D. Early bioenergetic changes in
hepatocarcinogenesis: preneoplastic phenotypes mimic responses to
insulin and thyroid hormone. J Bioenerg Biomembr 1997;29:303-13.
Conflicts of interest 3. Strnad P, Paschke S, Jang KH, Ku NO. Keratins: markers and
There are no conflicts of interest. modulators of liver disease. Curr Opin Gastroenterol 2012;28:209-16.
4. Su Q, Zerban H, Otto G, Bannasch P. Cytokeratin expression is reduced
REFERENCES in glycogenotic clear hepatocytes but increased in ground-glass cells
in chronic human and woodchuck hepadnaviral infection. Hepatology
1998;28:347-59.
1. Takegoshi K, Okada E, Nomoto K, Nobata K, Sawasaki T, Terada 5. Mathew J, Loranger A, Gilbert S, Faure R, Marceau N. Keratin 8/18
M, Terakawa H, Kobayashi T, Yabushita K, Sugimoto T, Terahata regulation of glucose metabolism in normal versus cancerous hepatic
S. Hepatocellular carcinoma and type 2 diabetes mellitus: two cases cells through differential modulation of hexokinase status and insulin
highlighting changes in tumor glycogen content. Hepatoma Res signaling. Exp Cell Res 2013;319:474-86.

230 Hepatoma Research | Volume 2 | August 5, 2016