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Fowler et al. Hepatoma Res 2020;6:19 I http://dx.doi.org/10.20517/2394-5079.2020.21 Page 5 of 10

A B C

D E F

Figure 4. Intrahepatic cholangiocarcinoma in a 51-year-old man with hepatitis-C related liver cirrhosis. CT scans in the arterial (A),
portal venous (B), and delayed (C) phases demonstrate a hypoattenuating hepatic nodule (arrow); C: the nodule shows a mild central
enhancement in the delayed phase; D: CEUS in the arterial phase shows a rim arterial-phase hyperenhancement in the nodule (arrow);
E: CEUS at 42 s after contrast injection demonstrates early washout (arrow); F: CEUS at 104 s after contrast injection shows marked
washout (arrow). CEUS: contrast enhanced ultrasound

A B C

D E F

Figure 5. Intrahepatic cholangiocarcinoma in a 78-year-old man with hepatitis-C related liver cirrhosis. A: CT scans in the arterial
phase shows a mass with rim arterial-phase hyperenhancement (arrows); CT scans in the portal venous (B), and delayed (C) phases
demonstrates gradual enhancement of the mass (arrows); C: there is also heterogeneous hyperenhancement in the delayed phase; D:
CEUS in the arterial phase shows irregular rim arterial-phase hyperenhancement in the mass (arrows); E: CEUS at 48 s after contrast
injection demonstrates early washout (arrows); F: CEUS at 115 s shows marked washout (arrows). CEUS: contrast enhanced ultrasound