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Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02 Page 31 of 50
Figure 51. Biotransformation of drug 283 with Cunninghamella elegans.
Figure 52. Biotransformation of mestranol (286) with Cunninghamella elegans.
Figure 53. Biotransformation of methyloestrenolone (289) with Macrophomina phaseolina.
7β, 15β, 16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21, 17-carbolactone (299) (3.1%), 6β,7β,15β
,16β-dimethylene-3, 11-dioxo-17α-pregn-4-ene-21, 17-carbolactone (300) (4.2%), 6β, 7β, 15β, 16β-
dimethylene-3, 12-dioxo-17α-pregn-4-ene-21, 17-carbolactone (301) (2.9%), and 6β, 7β, 15β, 16β-
dimethylene-3-oxo-11β, 14α-dihydroxy-17α-pregn-4-ene-21, 17-carbolactone (302) (6.2%), along with the
known metabolite, 6β, 7β, 15β, 16β-dimethylene-3-oxo-11α-dihydroxy-17α-pregn-4-ene-21, 17-carbolactone
(303) [Figure 55].
[76]
