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Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02 Page 29 of 50
Figure 48. Biotransformation of methasterone (255) with Macrophomina phaseolina and Cunninghamella blakesleeana.
Figure 49. Biotransformation of desogestrel (272) with Cunninghamella blakesleeana.
(Microplate Alamar Blue) assay.
Biotransformation of ethisterone (277)
Cunninghamella elegans-assisted transformation of another steroidal contraceptive compound, ethisterone (
277), afforded a new derivative, 17α-ethynyl-11α, 17β-dihydroxyandrost-4-en-3-one (278) (5.5%)
[72]
[Figure 50]. Biotransformation of the drug 277 with Cunninghamella blakesleeana afforded two new
metabolites, 17α-ethynyl-6β, 15β, 17β-trihydroxyandrost-4-en-3-one (279) (0.80%) and 17α-ethynyl-7β, 15β,
17β-trihydroxyandrost-4-en-3-one (280) (0.30%), while fermentation of ethisterone (277) with Aspergillus
