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Page 12 of 21 Carr et al. Vessel Plus 2020;4:12 I http://dx.doi.org/10.20517/2574-1209.2020.01

2% 2% 2% -7% 2% 2% 2% -7% -7% -11% -4% -2% -2% -2% -4% 0% 0% -2% 0% -2% -11% 0% -2% -2% -2% -7% 0% -13% -2% -4% -2% 0% -7% 0% -2% -2% -7% 0%

2% 2% 2% -5% 2% -5% 2% -15% -7% -5% 0% -2% -7% 0% 0% -2% 0% 0% 0% 0% 0% -5% -7% 0% -2% 0% -10% -7% 0% -15% 0% -7% 0% -2% -2% 0% 0% -7%

2% 2% 2% 2% 2% 2% 2% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0%

1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 61

Recent admissions Time from admission to procedure Center’s case frequency Ventricular or unstable arrhythmia PT or INR Disaster, catastrophic state Transfusion Cardiomegaly Aortic cross-clamp duration Endocarditis Abdominal aortic aneurysm Any family history variable Anemia (hemoglobin, hematocrit) Heart rate Steroid use ACE inhibitor use Functional state ASA classification Left ventricular hypertrophy Acute mental status changes Intraoperative

-10% 2% 0% 2% 0% -3% -5% -3% 0% 2% 2% 2% -5% 2% 0% 2% 2% 0% 2% 0% -2% 0% 0% 0% 0% 0% 0% -5% -10% -7% 0% 0% -2% 0% -7% 0% 0% -7%

4% 4% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 2% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0%

2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 73 Δa: change from < 1998; Δb: change from 1998-2007. Comb: combination variable; CHF: congestive heart failure; NYHA: New York Heart Association; MI: myocardial infarction; ECG: electrocardiogram; IABP: intra-aortic baloon pump; HTN: hypertension; BP: blood pressure; PCI: percutaneous coronary intervention; PTCA: percutaneous transluminal coron

Diffuse/severe disease Atrial arrhythmia Smoking status Date or order of surgery Any family history variable Anticoagulation or antiplatelet use Anemia (hemoglobin, hematocrit) Digoxin or digitalis use A published comorbidity index Heart rate ASA classification Acute mental status changes Ventricular wall motion Calcified aorta Type of MI Killip classification Blood pressure Other ECG abnormalities Preoperative thrombolysis Preoperative cardia

2% 2% 2% 2% 2% 2% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0% 0%

1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 60

Other preoperative comorbidities ACE inhibitor use Type of MI Atrial arrhythmia Antiarrhythmic agents Other ECG abnormalities Race or ethnicity Date or order of surgery On- vs. off-pump CABG Abdominal aortic aneurysm Hypercholesterolemia Critical state Heart rate Steroid use Preoperative cardiac biomarkers Functional state Patient education level/literacy ASA classification Insurance type or status Recent admissions Left ventricular hypertro