Page 246 - Read Online
P. 246

Martínez et al.                                                                                                                   Cardiomyocyte energetic changes in ischemia and arrythmogenesis

           thrombolysis and angioplasty, and very little practical   10.  Kleber  AG,  Saffitz  JE.  Role  of  the  intercalated  disc  in  cardiac
           value has been obtained from its study. Nonetheless,   propagation and arrhythmogenesis. Front Physiol 2014;5:404.
           the  evidence  suggesting  metabolic  causes  for   11.  Kurtenbach S, Kurtenbach S, Zoidl G. Gap junction modulation and
                                                                 its implications for heart function. Front Physiol 2014;5:82.
           arrhythmias grants a “resuscitation” of this cause [120] .   12.  Veeraraghavan R, Poelzing S,  Gourdie RG.  Intercellular  electrical
           Indeed, further research is required in order to explore   communication in the heart: a new, active role for the intercalated
           and exploit the therapeutic implications of myocardial   disk. Cell Commun Adhes 2014;21:161-7.
           metabolism.                                        13.  Rider O, Cox P, Tyler D, Clarke K, Neubauer S. Myocardial substrate
                                                                 metabolism in obesity. Int J Obes (Lond) 2012;37:972-9.
           DECLARATIONS                                       14.  Carley AN, Taegtmeyer H, Lewandowski ED. Mechanisms linking
                                                                 energy substrate metabolism  to the function of the heart.  Circ Res
                                                                 2014;114:717-29.
           Authors’ contributions                             15.  Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure
                                                                 - implications beyond ATP production. Circ Res 2013;113:709-24.
           Article conception and design: M.S. Martínez, A.   16.  Rosano G, Vitale C, Spoletini I. Metabolic approach to heart failure:
           García                                                the role of metabolic modulators. Egyptian Heart J 2015;67:177-81.
           Acquisition and analysis of bibliographic information:   17.  Long Q, Yang K, Yang Q. Regulation of mitochondrial ATP synthase
           M.S. Martínez, A. García, E. Luzardo, L.C. Olivar     in cardiac pathophysiology. Am J Cardiovasc Dis 2015;5:19-32.
           Drafting of the manuscript: M.S. Martínez, M. Chávez-  18.  Ingwall JS. Energy metabolism  in heart  failure  and remodelling.
           Castillo, J. Salazar                                  Cardiovasc Res 2009;81:412-9.
           Critical revision and final approval: V. Bermúdez, M.   19.  Wang J,  Guo T. Metabolic remodeling in chronic heart failure.  J
           Velasco, J.J. Rojas Quintero                          Zhejiang Univ Sci B 2013;14:688-95.
                                                              20.  Goldberg IJ, Trent CM, Schulze PC. Lipid metabolism and toxicity in
                                                                 the heart. Cell Metabolism 2012;15:805-12.
           Financial support and sponsorship                  21.  Wolf P, Winhofer Y, Krššák M, Krebs M. Heart, lipids and hormones.
           None.                                                 Endocr Connect 2017;6:R59-69.
                                                              22.  Abumrad NA, Goldberg IJ. CD36 actions  in the heart:  lipids,
           Conflicts of interest                                 calcium,  inflammation,  repair  and  more?  Biochim  Biophys  Acta
           There are no conflicts of interest.                   2016;1860:1442-9.
                                                              23.  Fukushima A, Lopaschuk GD. Cardiac fatty acid oxidation in heart
                                                                 failure associated with obesity and diabetes. Biochim Biophys Acta
           Patient consent                                       2016;1861:1525-34.
           Not applicable.                                    24.  Fukushima A, Milner K, Gupta A, Lopaschuk GD. Acetylation control
                                                                 of cardiac fatty acid β-oxidation and energy metabolism in obesity,
           Ethics approval                                       diabetes, and heart failure. Biochim Biophys Acta 2016;1862:2211-20.
           Not applicable.                                    25.  Fillmore N, Mori J, Lopaschuk GD. Mitochondrial fatty acid oxidation
                                                                 alterations  in  heart  failure,  ischaemic  heart  disease  and  diabetic
                                                                 cardiomyopathy. Br J Pharmacol 2014;171:2080-90.
           REFERENCES                                         26.  Glatz JF, Nabben M, Heather LC, Bonen A, Luiken JJ. Regulation of
                                                                 the subcellular trafficking of CD36, a major determinant of cardiac
                                                                 fatty acidutilization. Biochim Biophys Acta 2016;1861:1461-71.
           1.   D’Souza K, Nzirorera C, Kienesberger P. Lipid metabolism and signaling   27.  Pepino M, Kuda O, Samovski D, Abumrad N. Structure-function
               in cardiac lipotoxicity. Biochim Biophys Acta 2016;1861:1513-24.   of CD36 and importance  of fatty acid signal transduction  in fat
           2.   Gillespie  HS, Lin  CC, Prutkin  JM. Arrhythmias  in  structural  heart   metabolism. Ann Rev Nutr 2014;34:281-303.
               disease. Curr Cardiol Rep 2014;16:510.         28.  Glatz JF, Luiken JJ. From fat to FAT (CD36/SR-B2): understanding
           3.   Burton RA, Lee P, Casero R, Garny A, Siedlecka U, Schneider JE,   the regulation of cellular fatty acid uptake. Biochimie 2017;136:21-6.
               Kohl P, Grau V. Three-dimensional histology: tools and application   29.  Chanda  D, Luiken  JJ, Glatz  JF. Signaling  pathways involved  in
               to quantitative assessment of cell-type distribution in rabbit heart.   cardiac energy metabolism. FEBS Lett 2016;590:2364-74.
               Europace 2014;16 Suppl 4:iv86-95.              30.  Kim TT, Dyck JR. The role of CD36 in the regulation of myocardial
           4.   Maass K, Shekhar A, Lu J, Kang G, See F, Kim EE, Delgado C, Shen   lipid metabolism. Biochim Biophys Acta 2016;1861:1450-60.
               S, Cohen L, Fishman GI. Isolation and characterization of embryonic   31.  Kim TT, Dyck JR. Is AMPK the savior of the failing heart? Trends
               stem cell-derived cardiac Purkinje cells. Stem Cells 2015;33:1102-12.  Endocrinol Metab 2015;26:40-8.
           5.   Vigmond EJ, Stuyvers BD. Modeling our understanding of the His-  32.  Glatz JF, Angin Y, Steinbusch LK, Schwenk RW, Luiken JJ. CD36
               Purkinje system. Prog Biophys Mol Biol 2016;120:179-88.  as a target to prevent cardiac lipotoxicity  and insulin resistance.
           6.   Yin Z, Ren  J, Guo W. Sarcomeric  protein  isoform transitions  in   Prostaglandins Leukot Essent Fatty Acids 2013;88:71-7.
               cardiac  muscle:  a  journey  to  heart  failure.  Biochim  Biophys  Acta   33.  Samovski D, Su X, Xu Y, Abumrad N, Stahl P. Insulin and AMPK
               2015;1852:47-52.                                  regulate  FA translocase/CD36  plasma membrane  recruitment  in
           7.   Hu LY, Ackermann  MA, Kontrogianni-Konstantopoulos  A. The   cardiomyocytes via Rab GAP AS160 and Rab8a RabGTPase. J Lipid
               sarcomeric  M-region:  a molecular  command  center  for diverse   Res 2012;53:709-17.
               cellular processes. Biomed Res Int 2015;2015:714197.  34.  Angin Y, Steinbusch L, Simons P, Greulich S, Hoebers N, Douma K,
           8.   Katz A. Contractile proteins of the heart. Phys Rev 2016;50:63-158.  van Zandvoort MA, Coumans WA, Wijnen W, Diamant M, Ouwens
           9.   Gaztañaga L, Marchlinski F,  Betensky B. Mechanisms of cardiac   DM, Glatz JF, Luiken JJ. CD36 inhibition prevents lipid accumulation
               arrhythmias. Rev Esp Cardiol (Engl Ed) 2012;65:174-85.  and contractile  dysfunction in rat cardiomyocytes.  Biochem  J

            238                                                                                                                    Vessel Plus ¦ Volume 1 ¦ December 28, 2017
   241   242   243   244   245   246   247   248   249   250   251