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Alipov et al. Vessel Plus 2017;1:107-15 Vessel Plus
DOI: 10.20517/2574-1209.2017.20
www.vpjournal.net
Topic: Atherosclerosis and Related Diseases Open Access

Chemical composition of circulating native

and desialylated low density lipoprotein:

what is the difference?

Vladimir I. Alipov , Vasily N. Sukhorukov , Vasily P. Karagodin , Andrey V. Grechko , Alexander N. Orekhov 1,4
3
1,2
1
1
1 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
2 INSERM UMR_S 1166, Faculty of Medicine Pitie-Salpetriere, Bld de L’Hopital 91, University of Pierre and Marie Curie-Paris 6, 75013 Paris, France.
3 Federal Scientific Clinical Center for Resuscitation and Rehabilitation, 109240 Moscow, Russia.
4 Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.
Correspondence to: Mr. Vasily N. Sukhorukov, INSERM UMR_S 1166, Faculte de Medecine Pitie-Salpetriere, Bld de L’Hopital 91, University of Pierre
and Marie Curie - Paris 6, 75013 Paris, France. E-mail: vnsukhorukov@gmail.com
How to cite this article: Alipov VI, Sukhorukov VN, Karagodin VP, Grechko AV, Orekhov AN. Chemical composition of circulating native and
desialylated low density lipoprotein: what is the difference? Vessel Plus 2017;1:107-15.

ABSTRACT
Article history: Atherosclerosis and related cardiovascular disorders remain the leading global cause of
Received: 10 Jun 2017 morbidity and mortality. Modified low density lipoprotein (LDL) is considered to play a crucial
Accepted: 25 Aug 2017 role in atherosclerosis development. During the past decades, several types of atherogenic LDL
Published: 26 Sep 2017 modification have been discovered. Desialylation was one of the atherogenic modifications
observed in circulating atherogenic LDL in vivo. Sialic acid level negatively correlates with
Key words: triglyceride and cholesterol contents. Desialylated LDL is small, dense and highly susceptible
Desialylation, to oxidation, as reported for hyperlipidemic conditions. This atherogenic modification leads to
desialylated low density lipoprotein, increased cholesterol intake by macrophages and smooth-muscle cells, and is also associated
modified low density lipoprotein, with other pathologies, such as diabetes mellitus. Moreover, these conditions provoke damage
sialic acid, and desialylated LDL particles may trigger autoimmune reactions in macrophages and B-cells.
atherosclerosis

INTRODUCTION dendritic cells) and inflammation, followed by necrosis
and calcification. Elevated blood pressure, diabetes
[2]
Cardiovascular disease (CVD) is the leading cause of mellitus, hyperlipidemia, family history and smoking
morbidity and mortality worldwide. According to the are the major risk factors of atherosclerosis. These
American Heart Association, nearly 787,000 people conditions provoke damage and lipid penetration into
in the US died from heart disease, stroke or other the arterial wall. According to current understanding,
CVDs in 2011. Atherosclerosis underlies most of the plasma low density lipoprotein (LDL) plays a crucial
[1]
cardiovascular events in adults. Atherosclerotic plaque role in the pathogenesis of atherosclerosis because
formation involves accumulation of cholesterol and its of its ability to deliver cholesterol from the liver to
esters in the arterial intima, which results in migration peripheral tissues, including the arterial wall. On the
and proliferation of various cell types (smooth muscle other hand, high density lipoprotein (HDL) negatively
cells, macrophages, lymphocytes, neutrophils and correlates with CVD and has protective effects. [3,4]
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