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Lust et al. Vessel Plus 2021;5:7 I http://dx.doi.org/10.20517/2574-1209.2020.52 Page 11 of 14
Figure 5. Influence of diclofenac-treatment on SMC activation in mouse auricle veins. Selected auricle tissue segments (4 d after vein
ligation) containing remodeling veins were fixed, paraffin-embedded, cross-sectioned, and processed for immunostaining (nuclei were
visualized by DAPI staining). While PCNA (proliferation marker, A, arrows), MMP-2 (B, arrows), and COX-2 (C, arrows) were detectable in
cells of the remodeling veins, corresponding proteins were barely detected in diclofenac-treated auricles (arrows in D-F, scale bar: 50 μm).
In the vascular system, PGI2 as well as PGE2 are crucial for regulating vascular tone and inflammatory
responses via specific G-protein coupled receptors located on the surface of vascular endothelial and
[21]
smooth muscle cells. Indeed, PGI2 acts as the most relevant cardioprotective prostanoid . In line with
this, mutations/polymorphisms in the human prostacyclin synthase gene have been associated with stroke,
