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Smetanina et al. Vessel Plus 2021;5:19 Vessel Plus
DOI: 10.20517/2574-1209.2021.17

Perspective Open Access

The genetic constituent of varicose vein

pathogenesis as a key for future treatment option
development

1,2
3,4
3,4
Mariya A. Smetanina , Andrey I. Shevela , Konstantin A. Gavrilov , Maxim L. Filipenko 1,5
1
Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS, Novosibirsk
630090, Russia.
2
Department of Fundamental Medicine, V. Zelman Institute for Medicine and Psycology (NSU), Novosibirsk 630090, Russia.
3
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine (ICBFM) SB RAS, Novosibirsk
630090, Russia.
4
Department of Surgical Diseases, V. Zelman Institute for Medicine and Psycology (NSU), Novosibirsk 630090, Russia.
5
Department of Clinical Biochemistry, V. Zelman Institute for Medicine and Psycology (NSU), Novosibirsk 630090, Russia.
Correspondence to: Dr. Mariya A. Smetanina, Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental
Medicine (ICBFM) SB RAS, 8 Lavrentiev Avenue, Novosibirsk 630090, Russia. E-mail: mariya_smetanina@niboch.nsc.ru
How to cite this article: Smetanina MA, Shevela AI, Gavrilov KA, Filipenko ML. The genetic constituent of varicose vein
pathogenesis as a key for future treatment option development. Vessel Plus 2021;5:19. https://dx.doi.org/10.20517/2574-
1209.2021.17
Received: 31 Jan 2021 First Decision: 1 Mar 2021 Revised: 15 Mar 2021 Accepted: 24 Mar 2021 Available online: 17 Apr 2021

Academic Editor: Alexander D. Verin Copy Editor: Yue-Yue Zhang Production Editor: Yue-Yue Zhang

Abstract
This perspective focuses primarily on the fundamental part of phlebology, where most attention is paid to the
genetic aspects of the pathogenesis of varicose vein disease and where the main breakthrough advances in this
area of research are discussed. We propose a direction for further actions to replenish molecular genetic
knowledge about the main drivers of pathological processes in varicose vein disease and to complete the creation
of an entire picture of pathogenesis, which, in turn, may serve as a key for the development of treatment options in
the future in order to translate research evidence into clinical practice.

Keywords: Varicose veins, pathogenesis, genetics, epigenetics, targets

Varicose vein disease (VVD)-the main nosological form of chronic venous diseases-is a multifactorial
disease. Risk factors for developing venous pathologies include genetic factors and environmental factors.
The risk factors at their basis should be attributed to: (1) predisposing; and/or (2) affecting factors. Genetic,
as well as epigenetic, factors seem to be part of both (1) and (2): the mechanical effect leads to a cascade of

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made.

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