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Page 14 of 20 Nappi et al. Vessel Plus 2021;5:40 https://dx.doi.org/10.20517/2574-1209.2021.06

Table 3. Baseline characteristics of all patients in surgical approach groups [36-44]

r-MVR r-MVr Age, y, STS NYHA Class III or LVEF (%; mean ± Heart
Overall Sternotomy Thoracotomy
(%) (%) median score IV SD) failure

4 institutions within the Northwell Healt System 256 166 90 145 (56.6) 111 (43.4) 62.2 ± 14.7 8.1 ± 0.09 93 (56) 52.9 ± 12.6
Single Surgical Team (autors ACA and DHA) 53 44 9 45 (84.9) 8 (15.1) 57 ± 13.2 34 (64) 54.3 ± 10.8
Division of Cardiac Surgery of Maryland School of 130 130 0 41 (31) 39 (30) 62 ± 15 96 (74) 51 ± 12
Medicine
Mayo Clinic Rochester 145 N.I. N.I. 81 (56%) 64 (44) 69 (47,5) (n = 136)

Re-repair 64 64 ± 13 57 ± 12
Replacement 81 67 ± 11 56 ± 11

Michigan Medical Centre 450 0 450 NYHA Class
Fibrillatory Arrest 134 0 134 55 (41.1) 79 (58.9) 63 ± 13 2.7 ± 0.8 36 ± 13

Beating heart 316 0 316 101 (33) 215 (67) 63 ± 15 2.6 ± 0.7 38 ± 9
Pennsylvania Health System 305 249 56 257 48 LVEF < 40% (%)

Re-repair 61 ± 16 N.I. 10 (19)
Replacement 62 ± 15 N.I. 38 (15)
Medicare Provider Analysis and Review 1627 815 812 74 1275

Re-repair 285
Replacement 1332

A 10-year single-centre experience 49 49 63 ± 13
Division of Cardiovascular Surgery, Toronto General 513 57 ± 13 227 (44) < 40% (15%)
Hospital

STS: Society of Thoracic Surgeons; NYHA: New York Heart Association; LVEF: left ventricle ejection fraction; r-MVR: redo mitral valve replacement; r-MVr: redo mitral valve repair; N.I.: not indicated.

Regarding TMViV-T, the following is fundamental. First, the evaluation of clinically relevant endpoints should reflect the safety and efficacy of MRI
treatments. Second, consistent clinical definitions for these endpoints should be used across the relevant studies. The use of TMViV-T as mechanical

intervention is aimed to change the extent of the survival benefit. In contrast, the evidence on the use of a standard surgical approach has consistently shown
favorable results, and this option has gained the support of the surgical community.