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Flattery et al. Vessel Plus 2024;8:26 Vessel Plus
DOI: 10.20517/2574-1209.2023.130

Review Open Access

Clinical outcomes with intravascular ultrasound

guidance of percutaneous coronary interventions: a
targeted literature review of randomized controlled

trials

Erin Flattery, Louai Razzouk, Sunil V. Rao
Division of Cardiovascular Medicine, New York University Grossman School of Medicine, New York City, NY 10016, USA.
Correspondence to: Dr. Sunil V. Rao, Division of Cardiovascular Medicine, New York University Grossman School of Medicine,
550 1st Ave, New York city, NY 10016, USA. E-mail: Sunil.Rao@nyulangone.org

How to cite this article: Flattery E, Razzouk L, Rao SV. Clinical outcomes with intravascular ultrasound guidance of percutaneous
coronary interventions: a targeted literature review of randomized controlled trials. Vessel Plus 2024;8:26. https://dx.doi.org/10.
20517/2574-1209.2023.130
Received: 8 Oct 2023 First Decision: 1 Feb 2024 Revised: 18 Mar 2024 Accepted: 4 Jun 2024 Published: 28 Jun 2024

Academic Editors: Carlos A. Mestres, Giuseppe AndòCopy Editor: Fangyuan Liu Production Editor: Fangyuan Liu

Abstract
The use of intravascular ultrasound (IVUS) to guide and optimize percutaneous coronary intervention (PCI) has
been subject to robust clinical investigation for the last three decades. In this narrative review, we summarize the
major clinical outcomes of the randomized controlled trials evaluating the potential benefit of IVUS-guided PCI,
compared with either angiography alone or other coronary imaging and physiology technologies. These studies,
spanning decades and continents, provide the most rigorous evidence base that clinicians can use to guide real-
world decision making regarding the utility of IVUS guidance during PCI in contemporary clinical practice.

Keywords: Intravascular ultrasound (IVUS), percutaneous coronary intervention (PCI), coronary artery disease
(CAD)

INTRODUCTION
Intravascular ultrasound (IVUS) is a catheter-based intracoronary imaging technology that produces live,
[1]
cross-sectional, 360-degree images of the lumen and vascular anatomy of a coronary artery . Over the last
thirty years, this technology has been used in a broad array of clinical and research scenarios to assess

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing,
adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
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