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Orgun et al. Plast Aesthet Res 2017;4:32-40 Plastic and
DOI: 10.20517/2347-9264.2016.109
Aesthetic Research

www.parjournal.net
Review Open Access

Multipotency and secretome: the

mechanisms behind the regenerative

potential of adipose-derived stem cells

Doruk Orgun, Hiroshi Mizuno

Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Correspondence to: Dr. Hiroshi Mizuno, Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, 2-1-1 Hongo
Bunkyo-ku, Tokyo 113-8421, Japan. E-mail: hmizuno@juntendo.ac.jp

How to cite this article: Orgun D, Mizuno H. Multipotency and secretome: the mechanisms behind the regenerative potential of adipose-derived stem
cells. Plast Aesthet Res 2017;4:32-40.
Dr. Hiroshi Mizuno is currently appointed as a Professor and Chief, Department of Plastic and Reconstructive Surgery,
Juntendo University School of Medicine, Tokyo, Japan. Dr. Mizuno’s clinical interests include breast reconstruction, burn
reconstructive surgery, limb salvage surgery and blepharoplasty. In addition, Dr. Mizuno have been involved in basic
research with regard to adipose-derived stem cells and control-released growth factors for regenerative medicine and
wound healing. Dr. Mizuno is a former visiting fellow at Division of Plastic Surgery, University of California, Los Angeles
(UCLA), where he was one of the core members who firstly discovered mesodermal stem cells within adipose tissue.

ABSTRACT
Article history: The use of stem cells for regenerating damaged organs and tissues which are unable to
Received: 23-12-2016 heal on their own is a widely studied field in plastic and reconstructive surgery as well as
Accepted: 09-03-2017 medicine in general. Among various stem cell types, adipose-derived stem cells (ASCs)
Published: 22-03-2017 are especially considered to be an ideal stem cell population for several clinical situations.
These cells could be harvested from fat with relatively less invasive methods with high
Key words: yield rates. ASCs have proved to be worthy of more research to understand the mechanisms
Stem cell transplantation, behind their regenerative abilities. However, it remains uncertain if ASCs show their main
paracrine communication, effects by their multipotency, or by secreting abundant amounts of cytokines and growth
angiogenesis, factors. The authors have performed a review of the current publications and literature on the
wound healing, ASCs’ immunophenotypical properties and isolation methods as well as basic and clinical
radiation injuries, science research about the mechanisms behind their regenerative effects. The purpose of this
macrophages (M2 subtype) article is to synthesize information regarding ASCs’ paracrine effects and their ability to
differentiate into other cell lines, comparing these aspects in order to lead future research for
a more effective cell therapy utilizing these cells.

INTRODUCTION and passionate desire to simulate and recreate the
phenomenon of this very complex existence to satisfy
The concepts of creation and construction have always our curiosity, and also as physicians to heal.
fascinated us human beings. With better understanding
of human body, we also began to feel a powerful The innate regeneration capacity of various tissues led
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