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Hwang et al. In vivo degradation of PLDLA-TMC

Chapanian and Amsden investigated the potential REFERENCES
[10]
of osmotic pressure-driven release of proteins from 1. van der Elst M, Dijkema AR, Klein CP, Patka P, Haarman HJ. Tissue
poly(TMC-co-DLLA) elastomers with varying amounts reaction on PLLA versus stainless steel interlocking nails for fracture
of DLLA, using bovine serum albumin (BSA) as a fixation: an animal study. Biomaterials 1995;16:103-6.
model protein. The BSA was co-lyophilized with either 2. Pistner H, Bendix DR, Mühling J, Reuther JF. Poly(L-lactide): a long-
trehalose or trehalose combined with sodium chloride as term degradation study in vivo. Part III. Analytical characterization.
Biomaterials 1993;14:291-8.
osmotigens to produce particles with sufficient osmotic 3. Imola MJ, Hamlar DD, Shao W, Chowdhury K, Tatum S. Resorbable
activity. plate fixation in pediatric craniofacial surgery: long-term outcome.
Arch Facial Plast Surg 2001;3:79-90.
The reduced molecular weights in the post-insertion 4. Landes CA, Ballon A, Roth C. Maxillary and mandibular
specimen suggest that PLDLA-TMC has favorable osteosyntheses with PLGA and P(L/DL)LA implants: a 5-year
degradation properties. The newly appeared bands are inpatient biocompatibility and degradation experience. Plast Reconstr
Surg 2006;117:2347-60.
thought to be an amide peak (1,670-1,640 cm ) and its 5. Matsumura S, Tsukada K, Toshima K. Novel lipase-catalyzed ring-
-1
stretch bend (1,640-1,550 cm ), resulting from serum or opening copolymerization of lactide and trimethylene carbonate
-1
tissue fluid incorporation. forming poly(ester carbonate)s. Int J Biol Macromol 1999;25:161-7.
6. Yang J, Liu F, Tu S, Chen Y, Luo X. Lu Z, Wei J, Li S. Haemo- and
Financial support and sponsorship cytocompatibility of bioresorbable homo- and copolymers prepared
from 1,3-trimethylene carbonate, lactides, and epsilon-caprolactone.
This study was supported by Inha University (INHA- J Biomed Mater Res A 2010;94:396-407.
Research Grant). 7. Guo Q, Lu Z, Zhang Y, Li S, Yang J. In vivo study on the
histocompatibility and degradation behavior of biodegradable
Conflicts of interest poly(trimethylene carbonate-co-D,L-lactide). Acta Biochim Biophys
Sin (Shanghai) 2011;43:433-40.
There are no conflicts of interest. 8. Pêgo AP, Siebum B, Van Luyn MJ, Gallego y Van Seijen XJ,
Poot AA, Grijpma DW, Feijen J. Preparation of degradable porous
Patient consent structures based on 1,3-trimethylene carbonate and D,L-lactide (co)
Obtained. polymers for heart tissue engineering. Tissue Eng 2003;9:981-94.
9. Pêgo AP, Van Luyn MJ, Brouwer LA, van Wachem PB, Poot AA,
Grijpma DW, Feijen J. In vivo behavior of poly(1,3-trimethylene
Ethical approval carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-
All procedures performed in studies involving human lactide or epsilon-caprolactone: degradation and tissue response. J
Biomed Mater Res A 2003;67:1044-54.
participants were in accordance with the ethical 10. Chapanian R, Amsden BG. Osmotically driven protein release from
standards of the institutional and/or national research photo-cross-linked elastomers of poly(trimethylene carbonate) and
committee and with the 1964 Helsinki Declaration and poly(trimethylene carbonate-co-d,l-lactide). Eur J Pharm Biopharm
its later amendments or comparable ethical standards. 2010;74:172-83.

12 Plastic and Aesthetic Research ¦ Volume 4 ¦ January 19, 2017