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Table 5: CI and P value which suggests that results were significant
Baseline 1st visit 2nd visit 3rd visit 4th visit 5th visit 6th visit Final visit
Area 10.98 8.42 6.24 4.57 3.06 2.02 1.36 1.13
P value 0.1706 0.0125 0.0004 <0.0001 <0.0001 <0.0001 <0.0001
CI −1.11–6.14 1.05–8.33 2.95–9.76 4.71–11.03 5.88–11.94 6.59–12.55 6.93–12.76
Volume 5.19 3.53 2.19 1.26 0.73 0.42 0.23 0.39
P value 0.1160 0.0020 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
CI −0.42–3.74 1.14–4.84 2.23–5.62 2.83–6.08 3.18–6.36 3.38–6.54 3.21–6.38
CI: Confidence interval

Figure 7: 24 bit (true color) venous ulcer of 6 months duration healed
after three sittings of platelet rich plasma

Figure 6: 24 bit (true color) traumatic ulcer of 2 months duration healed
after two sittings of platelet rich plasma

Figure 9: 24 bit (true color) traumatic ulcer of 4 months duration healed
after three sittings of platelet rich plasma

Figure 8: 24 bit (true color) trophic ulcer of 3 months duration healed
within 2 weeks

Figure 11: 24 bit (true color) venous ulcer of 7 months duration healed
after six sittings of platelet rich plasma

in response to platelet activation by inducers of platelet
aggregation. [10]
The anti‑inflammatory factors in PRP also play a role in
wound healing because of the presence of leukocytes,
which are at high levels in PRP. [8]
In addition to the GFs, platelets release numerous
other substances (e.g. fibronectin, vitronectin, and
sphingosine 1‑phosphate) that are important in wound
healing. An advantage of PRP over the use of single
recombinant human GF delivery is the release of
Figure 10: 24 bit (true color) traumatic ulcer healed after one sitting of multiple GFs and differentiation of factors upon platelet
platelet rich plasma
activation. [11]
mesenchymal cell recruitment, proliferation, extracellular There is no standard method of preparation of PRP
matrix degeneration, and cell differentiation for tissue in literature. According to Marx, to truly concentrate
regeneration. These factors are released from α granules platelets from autologous blood, the device must use

68 Plast Aesthet Res || Vol 1 || Issue 2 || Sep 2014