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Figure 2: The sum of the mean area of the ulcers from baseline to last visit

Figure 3: The sum of the mean volume of ulcers from baseline to last visit

Figure 4: Percentage improvement in area of the ulcers

Table 3: Improvement of area of the ulcer in percentage Figure 5: Percentage improvement in volume of the ulcers
at the end of 6th sitting
Percentage improvement in Number Percentage of healthcare settings and are a challenge for healthcare
area at the end of 6th sitting of ulcers providers. Chronic nonhealing ulcers are often difficult to
<60 3 10 treat. Conventional therapies such as dressings, surgical
61–70 0 0 debridement, and even skin grafting cannot provide
71–80 4 12 satisfactory healing since these treatments are not able
81–90 0 0 to provide the necessary GFs to modulate the healing
91–100 26 78 process. [8]

In 1986, Knighton et al. showed that the accelerated
[9]
Table 4: Improvement of volume in percentage at the epithelialization of granulation tissue leading to
end of 6th sitting complete repair of chronic nonhealing ulcers is
Percentage improvement in Number Percentage attainable by the use of autologous platelet factors.
volume at the end of 6th sitting of ulcers This was the first clinical demonstration that locally
<60 2 6 acting factors derived from autologous blood promote
61–70 0 0 healing of chronic cutaneous ulcers. In this study, the
71–80 0 0 time to 100% healing after initiation of platelet‑derived
81–90 3 10 wound‑healing factors (PDWHF) was 7.5 ± 6.5 weeks.
91–100 28 84 There was a direct correlation between the initiation
of PDWHF therapy and 100% healing. The age of
the patients and the location of the ulcers had no
reduction in pain and discharge within 1 week due to the
anti‑inflammatory property of PRP, which contains leukocytes. statistically significant effect on PDWHF‑stimulated
There were no side effects reported. wound repair.
Platelet‑rich plasma enhances wound healing by
DISCUSSION promoting the healing process secondary to its GFs.
These include platelet‑derived GF (αα, ββ, and αβ),
Chronic wounds come with cost and morbidity for fibroblast GF, vascular endothelial GF, epidermal GF,
patients and society. These wounds are found in all types insulin‑like GF, and transforming GF. These GFs stimulate

Plast Aesthet Res || Vol 1 || Issue 2 || Sep 2014 67