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Topic: EuRePS Meeting 2015: best five papers

Application of regenerative medicine in

treatment of acne scars

Mauro Barone , Stefania Tenna , Annalisa Cogliandro , Vincenzo Panasiti , Carolina
1
1
1
1
Nobile , Paolo Persichetti 1
2
1 Department of Plastic Reconstructive and Aesthetic Surgery, Campus Bio-Medico University of Rome, 00128 Roma, Italy.
2 Department of Ematology, Campus Bio-Medico University of Rome, 00128 Roma, Italy.
Address for correspondence: Dr. Mauro Barone, Department of Plastic Reconstructive and Aesthetic Surgery, Campus Bio-Medico
University of Rome, Via Alvaro del Portillo, 21, 00128 Roma, Italy. E-mail: maurosabbarone@gmail.com

ABSTRACT
Aim: The aim of this study is to evaluate the efficacy of the protocol of nanofat and platelet-rich
plasma (PRP) infiltration and fractional CO laser resurfacing for face atrophic scars by acne
2
and to analyse patient’s satisfaction with the original questionnaire. Methods: From March
2014 to June 2015, 30 patients with acne scarsonthe cheeks were selected for this pilot study.
Patients were evaluated pre- and postoperatively by a physical examination, photographs and
ultrasound scan with a 22 MHz probe to measure subcutaneous tissue thickness. All patients
were treated by infiltration of nanofat and PRP. The production of PRP was achieved by
RegenLab THT tube method. Subsequently, patients were randomly divided into two groups:
®
group A, which also underwent a fractional CO laser resurfacing at 15 W; and group B, which
2
only underwent nanofat and PRP infiltration. The original questionnaire of quality of life
questionnaire (QoL-Q) was also administered pre- and postoperatively to analyse satisfaction
and aesthetical perception of the result. Results: Preoperative thickness of subcutaneous
tissue of patients from group A was 0.532 mm, whilst preoperative thickness of subcutaneous
tissue of patients from group B was 0.737 mm. Postoperative thickness of subcutaneous
tissue was 1.201 mm in group A and 1.367 mm in group B. The improvement of thickness of
subcutaneous tissue was 0.668 mm in group A and 0.630 mm in group B. The authors applied a
t-test on unpaired data, comparing the difference in thickness obtained with the treatment both
in group A and in group B, with a P = 0.7289 (not significant). All patients in both groups had
a treatment benefit. Conclusion: Combined approach with nanofat, PRP and CO laser seems
2
to be effective to improve trophic scars, however, infiltration alone proved to significantly
increase skin and subcutaneous tissue thickness. QoL-Q confirmed the impact of acne scars on
the face in social life and relationships.

Key words:
Acne; scars; regenerative; laser; nano-fat

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How to cite this article: Barone M, Tenna S, Cogliandro A, Panasiti
DOI: V, Nobile C, Persichetti P. Application of regenerative medicine in
10.20517/2347-9264.2016.42 treatment of acne scars. Plast Aesthet Res 2016;3:235-9.
Received: 02-06-2016; Accepted: 22-06-2016
© 2016 Plastic and Aesthetic Research | Published by OAE Publishing Inc. 235