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Topic: State of the Art in the Management of Oral Squamous Cell Carcinoma

The role of salvage surgery in oral

squamous cell carcinoma

Raúl González-García

Department of Oral and Maxillofacial-Head and Neck Surgery, University Hospital Infanta Cristina, 06080 Badajoz, Spain.
Correspondence Author: Prof. Raúl González-García, Department of Oral and Maxillofacial-Head and Neck Surgery, University
Hospital Infanta Cristina, 06080 Badajoz, Spain. E-mail: raulmaxilo@gmail.com
Prof. Raúl González-García, M.D., Ph.D, FEBOMFS, was graduated in Medicine (Medical Degree, M.D.)
by the Universidad Autónoma de Madrid School of Medicine, Madrid, Spain, in 2001, and obtained his
trainee in Oral and Maxillofacial Surgery in the University Hospital La Princesa, Madrid, Spain, in 2007.
He obtained his Ph.D. Degree in Medicine and Surgery at the Universidad Autónoma de Madrid School of
Medicine, in 2011. Since 2007 he is Consultant Surgeon at the Department of Oral and Maxillofacial Surgery,
University Hospital Infanta Cristina, Badajoz, Spain, and he is also a University Honorary Collaborator at
the Universidad de Extremadura School of Medicine. He is actually Editor-in-Chief of Plastic and Aesthetic
Research, Assistant Director of Revista Española de Cirugía Oral y Maxilofacial, Permanent Member of the
Reviewer Commitee of International Journal of Oral and Maxillofacial Surgery, Contributing Editor of Current
Research in Dentistry, and Member of the Editorial Board/reviewer of more than 35 international journals
of the speciality. He is author of more than 130 publications, 96 of them in international Medline/PubMed-
indexed journals, 15 chapters in books of the speciality, and he is author of the text book "Reconstrucción
Maxilomandibular Compleja: Microcirugía, Distracción Ósea e Implantes dentales".
ABSTRACT
Aim: To select and analyze the most representative papers published in the literature concerning
oral squamous cell carcinoma (OSCC), specifically dealing with salvage surgery following primary
treatment by surgery with or without by postoperative radiotherapy, specifically focusing in the
oral cavity and oropharynx locations. Methods: A bibliography search on MEDLINE and EMBASE
databases for studies published from March 2000 to March 2016 was conducted. The authors only
included studies published in the English language and those dealing with “squamous cell carcinoma
of the oral cavity and/or oropharynx”. The following technical bibliographic exclusion criteria
were applied: (1) case reports; (2) technical report; (3) animal or in vitro studies; (4) review articles;
(5) uncontrolled clinical studies; and (6) publications in which the same data were published by the
same group of researchers. The abstracts of yielded results were reviewed and the full text of those
with apparent relevance was obtained. Results: A total amount of 188 studies were found using the
above reported searching parameters. Thirteen original papers were finally selected according to
the inclusion and exclusion criteria. From 1,692 analyzed patients, overall recurrence rate was 26%
(range: 15-41.7%), with a mean 47.3%, 35.1% and 10.9% local, regional and loco-regional recurrence,
respectively. Mean 5-year overall survival rate was 40.2% (range: 37.5-42.9%). Conclusion: Salvage
surgery is the best option for the treatment of recurrent OSCC, either local, regional or loco-regional,
with the highest rates in terms of survival and with an acceptable morbidity.

Key words:
Salvage surgery; oral squamous cell carcinoma; recurrent oral cancer

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How to cite this article: González-García R. The role of salvage
surgery in oral squamous cell carcinoma. Plast Aesthet Res
DOI:
10.20517/2347-9264.2016.43 2016;3:189-96.
Received: 07-06-2016; Accepted: 17-06-2016
© 2016 Plastic and Aesthetic Research | Published by OAE Publishing Inc. 189