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contralateral neck dissection plus adjuvant CCRT can 7. Capote-Moreno A, Naval L, Muñoz-Guerra MF, Sastre J, Rodríguez-
only be answered in a prospective trial. Campo FJ. Prognostic factors in uencing contralateral neck lymph node
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elective treatment modality, the threshold for treating in oral cavity squamous cell carcinoma. Head Neck 2006;28:896-901.
the contralateral neck is low, taking in mind the difficulty 9. Bier-Laning CM, Durazo-Arvizu R, Muzaffar K, Petruzzelli GJ. Primary tumor
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12. González-García R, Naval-Gías L, Rodríguez-Campo FJ, Sastre-Pérez
J, Muñoz-Guerra MF, Gil-Díez Usandizaga JL. Contralateral lymph
The OSCC presents a variable incidence of CLNM, reported neck node metastasis of squamous cell carcinoma of the oral cavity:
between 0.9% to 36% and it has been widely accepted a retrospective analytic study in 315 patients. J Oral Maxillofac Surg
that CLNM dramatically reduce long-term survival and 2008;66:1390-8.
prognosis. Several predictive factors have been proposed 13. Feng Z, Niu LX, Yuan Y, Peng X, Guo CB. Risk factors and treatment
to be correlated with the risk of contralateral lymph node of contralateral neck recurrence for unilateral oral squamous
cell carcinoma: a retrospective study of 1482 cases. Oral Oncology
metastasis, such as tumor location, size or thickness, 2014;50:1081-8.
ipsilateral lymph node metástasis, ECS, TNM stage, 14. Huang SF, Wei FC, Liao CT, Wang HM, Lin CY, Lo S, Huang JJ, Chen IH,
surgical margins, grade of hystological differentiation, Kang CJ, Chien HT, Chen HH. Risk stratification in oral cavity squamous
tumor satellite distance, perineural and lymphovascular cell carcinoma by preoperative CRP and SCC antigen levels. Ann Surg
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invasion, peritumoral inflammation and local recurrence. 15. Shingaki S, Takada M, Sasai K, Bibi R, Kobayashi T, Nomura T, Saito C.
Impact of lymph node metastasis on the pattern of failure and survival
It is important for clinicians to pay careful attention in oral carcinomas. Am J Surg 2003;185:278-84.
to these prognostic variables that must be globally 16. Greenberg JS, El Naggar AK, Mo V, Roberts D, Myers JN. Disparity in
pathologic and clinical lymph node staging in oral tongue carcinoma.
considered for each individual case. Surgeons should Cancer 2003;98:508-15.
take into account the detailed and individual study of 17. Jang WI, Wu HG, Park CI, Kim KH, Sung MW, Kim MJ, Choung PH, Lee
risks and potential benefits of elective neck treatment JH, Chao JY. Treatment of patients with clinically lymph node-negative
for contralateral N0 neck while considering a small squamous cell carcinoma of the oral cavity. Jpn J Clin Oncol 2008;38:395-
401.
percentage of patients with oral carcinoma that finally 18. Vandenbrouck C, Sancho-Garnier H, Chassagne D, Saravane D, Cachin
develop CLNM. Y, Micheau C. Elective versus therapeutic radical neck dissection in
epidermoid carcinoma of the oral cavity: results of a randomized clinical
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Financial support and sponsorship 19. Snow GB, Annyas AA, van Slooten EA, Bartelink H, Hart AA. Prognostic
Nil. factors of neck node metastasis. Clin Otolaryngol Allied Sci 1982;7:185-92.
20. González-García R, Naval-Gías L, Sastre-Pérez J, Rodriguez-Campo
Conflicts of interest FJ, Muñoz-Guerra MF, Gil-Diez Usandizaga JL, Diaz-Gonzalez FJ.
Contralateral lymph neck node metastasis of primary squamous cell
There are no conflicts of interest. carcinoma of the tongue: a retrospective analytic study of 203 patients.
Int J Oral Maxillofac Surg 2007;36:507-13.
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