Page 43 - Read Online

Toscano et al. Neuroimmunol Neuroinflammation 2021;8:14-41 I http://dx.doi.org/10.20517/2347-8659.2020.12 Page 39

197. Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-gort R, et al. Repeated subcutaneous injections of IL12/23 p40
neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled,
randomised, dose-ranging study. Lancet Neurol 2008;7:796-804.
198. Matusevicius D, Kivisäkk P, He B, Kostulas N, Ozenci V, et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is
augmented in multiple sclerosis. Mult Scler 1999;5:101-4.
199. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets
validated in autoimmune encephalomyelitis. Nat Med 2002;8:500-8.
200. Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E. Phenotypical and functional characterization of T helper 17 cells
in multiple sclerosis. Brain 2009;132:3329-41.
201. Havrdová E, Belova A, Goloborodko A, Tisserant A, Wright A, et al. Activity of secukinumab, an anti-IL-17A antibody, on brain lesions
in RRMS: results from a randomized, proof-of-concept study. J Neurol 2016;263:1287-95.
202. Ishizu T, Osoegawa M, Mei FJ, Kikuchi H, Tanaka M, et al. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis.
Brain 2005;128:988-1002.
203. Rossi S, Motta C, Studer V, Barbieri F, Buttari F, et al. Tumor necrosis factor is elevated in progressive multiple sclerosis and causes
excitotoxic neurodegeneration. Mult Scler 2014;20:304-12.
204. Trenova AG, Slavov GS, Draganova-Filipova MN, Mateva NG, Manova MG, et al. Circulating levels of interleukin-17A, tumor necrosis
factor-alpha, interleukin-18, interleukin-10, and cognitive performance of patients with relapsing-remitting multiple sclerosis. Neurol Res
2018;40:153-9.
205. Pegoretti V, Baron W, Laman JD, Eisel ULM. Selective Modulation of TNF-TNFRs Signaling: insights for multiple sclerosis treatment.
Front Immunol 2018;9:925.
206. Caminero A, Comabella M, Montalban X. Tumor necrosis factor alpha (TNF-α), anti-TNF-α and demyelination revisited: an ongoing
story. J Neuroimmunol 2011;234:1-6.
207. Brambilla R, Ashbaugh JJ, Magliozzi R, Dellarole A, Karmally S, et al. Inhibition of soluble tumour necrosis factor is therapeutic in
experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination. Brain 2011;134:2736-54.
208. Ng LG, Sutherland AP, Newton R, Qian F, Cachero TG, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the
principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 2004;173:807-17.
209. Kannel K, Alnek K, Vahter L, Gross-Paju K, Uibo R, et al. Changes in blood B cell-activating factor (BAFF) levels in multiple sclerosis:
a sign of treatment outcome. PLoS One 2015;10:e0143393.
210. Friede RL, Samorajski T. Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice. Anat Rec
1970;167:379-87.
211. Varhaug KN, Torkildsen Ø, Myhr KM, Vedeler CA. Neurofilament light chain as a biomarker in multiple sclerosis. Front Neurol
2019;10:338.
212. Rosengren LE, Karlsson JE, Karlsson JO, Persson LI, Wikkelsø C. Patients with amyotrophic lateral sclerosis and other neurodegenerative
diseases have increased levels of neurofilament protein in CSF. J Neurochem 1996;67:2013-8.
213. De Schaepdryver M, Jeromin A, Gille B, Claeys KG, Herbst V, et al. Comparison of elevated phosphorylated neurofilament heavy chains
in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2018;89:367-73.
214. Fyfe I. Alzheimer disease: neurofilament light in the blood marks Alzheimer degeneration. Nat Rev Neurol 2017;13:257.
215. Meeter LH, Dopper EG, Jiskoot LC, Sanchez-Valle R, Graff C, et al. Neurofilament light chain: a biomarker for genetic frontotemporal
dementia. Ann Clin Transl Neurol 2016;3:623-36.
216. Mages B, Aleithe S, Altmann S, Blietz A, Nitzsche B, et al. Impaired neurofilament integrity and neuronal morphology in different
models of focal cerebral ischemia and human stroke tissue. Front Cell Neurosci 2018;12:161.
217. Byrne LM, Rodrigues FB, Blennow K, Durr A, Leavitt BR, et al. Neurofilament light protein in blood as a potential biomarker of
neurodegeneration in Huntington’s disease: a retrospective cohort analysis. Lancet Neurol 2017;16:601-9.
218. Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE, et al; and the NFL Group. Diagnostic value of cerebrospinal fluid
neurofilament light protein in neurology: a systematic review and meta-analysis. JAMA Neurol 2019;76:1035-48.
219. Bergman J, Dring A, Zetterberg H, Blennow K, Norgren N, et al. Neurofilament light in CSF and serum is a sensitive marker for axonal
white matter injury in MS. Neurol Neuroimmunol Neuroinflamm 2016;3:e271.
220. Novakova L, Zetterberg H, Sundström P, Axelsson M, Khademi M, et al. Monitoring disease activity in multiple sclerosis using serum
neurofilament light protein. Neurology 2017;89:2230-7.
221. Kuhle J, Barro C, Disanto G, Mathias A, Soneson C, et al. Serum neurofilament light chain in early relapsing remitting MS is increased
and correlates with CSF levels and with MRI measures of disease severity. Mult Scler 2016;22:1550-9.
222. Kuhle J, Barro C, Andreasson U, Derfuss T, Lindberg R, et al. Comparison of three analytical platforms for quantification of the
neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa. Clin Chem Lab Med
2016;54:1655-61.
223. Disanto G, Barro C, Benkert P, Naegelin Y, Schädelin S, et al; Swiss Multiple Sclerosis Cohort Study Group. Serum neurofilament light:
a biomarker of neuronal damage in multiple sclerosis. Ann Neurol 2017;81:857-70.
224. Teunissen CE, Iacobaeus E, Khademi M, Brundin L, Norgren N, et al. Combination of CSF N-acetylaspartate and neurofilaments in
multiple sclerosis. Neurology 2009;72:1322-9.
225. Kuhle J, Leppert D, Petzold A, Regeniter A, Schindler C, et al. Neurofilament heavy chain in CSF correlates with relapses and disability
in multiple sclerosis. Neurology 2011;76:1206-13.