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Verma et al. Neuroimmunol Neuroinflammation 2018;5:20 Neuroimmunology and
DOI: 10.20517/2347-8659.2017.65 Neuroinflammation

Case Report Open Access

Hypoparathyroidism presenting with late onset
seizures - a report of two cases from rural India

Archana Verma , Alok Kumar 2
1
1 Department of Neurology, Uttar Pradesh University Medical Sciences, Etawah 206301, India.
2 Department of Forensic Medicine & Toxicology, Uttar Pradesh University of Medical Sciences, Etawah 206130, India.
Correspondence to: Prof. Archana Verma, Department of Neurology, Uttar Pradesh University of Medical Sciences, State UP, Saifai,
Etawah 206301, India. E-mail: archanashiva2010@rediffmail.com

How to cite this article: Verma A, Kumar A. Hypoparathyroidism presenting with late onset seizures - a report of two cases from
rural India. Neuroimmunol Neuroinflammation 2018;5:20. http://dx.doi.org/10.20517/2347-8659.2017.65

Received: 28 Dec 2017 First Decision: 25 Feb 2018 Revised: 12 Mar 2018 Accepted: 23 Apr 2018 Published: 23 May 2018

Science Editor: Athanassios P. Kyritsis Copy Editor: Guang-Zhe Zhu Production Editor: Huan-Liang Wu

ABSTRACT
Hypoparathyroidism leading to hypocalcaemia is an important treatable cause of recurrent seizures. Neurological
manifestations due to hypoparathyroidism include: seizures, paresthesia, depression, psychosis, extra pyramidal
symptoms, and features of raised intracranial pressure. Seizures may be the presenting symptoms preceding
other signs of hypocalcaemia. Primary hypoparathyroidism presenting for the first time as seizures in the elderly
is quite rare. Here we report two cases of hypoparathyroidism presenting with seizures in the elderly as the sole
manifestation of hypocalcaemia. The goal of this report is to seek attention to such an uncommon reversible
treatable cause of seizures and to consider hypoparathyroidism in the work up of these patients.

Keywords: Late onset seizures, hypoparathyroidism, hypocalcemia

INTRODUCTION
Hypoparathyroidism occurs when too little parathyroid hormone (PTH) is released from the
[1]
parathyroid glands, or the released PTH does not work properly . Common clinical manifestations of
hypoparathyroidism include tingling and numbness, carpopedal spasm, neurocognitive dysfunction and
seizures. Hypoparathyroidism and pseudohypoparathyroidism (due to deficient end-organ response to PTH)
are the most familiar reasons for pathological basal ganglia calcification.

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
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