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Jia et al. Neuroimmunol Neuroinflammation 2017;4:61-4 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.51
Neuroinflammation

www.nnjournal.net
Case Report Open Access

Two cases of Guillain-Barré syndrome after

cerebral hemorrhage or head trauma

Huan Jia , Ye Tian , Yan-Min Wu , Bin Li 1,2
1
1
1
1 Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China.
2 Key Laboratory of Hebei Neurology, Shijiazhuang 050000, Hebei, China.
Correspondence to: Prof. Bin Li, Department of Neurology, The Second Hosipital of Hebei Medical University, Key Laboratory of Hebei Neurology,
Heping West Road 215, Shijiazhuang 050000, Hebei, China. E-mail: jack511@163.com
How to cite this article: Jia H, Tian Y, Wu YM, Li B. Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma.
Neuroimmunol Neuroinflammation 2017;4:61-4.

Prof. Bin Li works in the Department of Neurology, the Second Hospital of Hebei Medical University. She is a youth
committee member of Neurology Branch of Chinese Medical Association. Her main research programs focus on
neuroimmunology.

ABSTRACT

Article history: Guillain-Barré syndrome (GBS) is an uncommon disease involving widespread peripheral
Received: 23-11-2016 nerve inflammatory demyelination which results in ascending symmetrical limb paralysis and
Accepted: 24-02-2017 areflexia. Approximately 2/3 of cases occurred following a simple, trivial antecedent infection.
Published: 12-04-2017 In northern China, diarrhea caused by Campylobacter jejuni is the most common etiology
of GBS. This article presents 2 cases - post cerebral hemorrhage and post head traumatic
Key words: GBS. Both patients suffered from acute motor axonal neuropathy, a main subtype of GBS, 14
Guillain-Barré syndrome, days after cerebral hemorrhage or head trauma without any antecedent infection. The possible
cerebral hemorrhage, pathophysiological mechanisms are discussed in the article, and the importance of increasing
trauma, the awareness of early diagnosis, as well as early treatment with intravenous immunoglobulin
anti-ganglioside antibodies and supportive care, in this special pathogenic GBS is emphasized.

INTRODUCTION nerves, which causes demyelination. As far as we
[1]
know, various factors can result in GBS. Almost 2/3 of
Guillain-Barré syndrome (GBS) is an acute inflammatory GBS patients suffer from bacterial or viral infections
polyneuropathy that primarily damages human spinal within 1-4 weeks before onset. Campylobacter jejuni
nerve roots and peripheral nerves. One of the possible (C. jejuni) is the most common pathogen of the
pathological changes is lymphocyte and macrophage prodromal infection especially in northern China.
infiltration around the small blood vessels of peripheral The most common pathogenesis of GBS is mainly

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