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Koseki et al. Neuroimmunol Neuroinflammation 2016;3:173-9 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.05
Neuroinflammation

www.nnjournal.net
Review Open Access

Population of inflammatory cells in

intracranial aneurysm with the special

insight to the development of novel

diagnostic and therapeutic approaches

Hirokazu Koseki 1,2,3 , Tomohiro Aoki 1,3

1 Center for Innovation in Immunoregulation Technologies and Therapeutics (AK project), Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
2 Department of Neurosurgery, Tokyo Women’s Medical University Medical Center East, Tokyo 116-8567, Japan.
3 Core Research for Evolutional Science and Technology (CREST) from Japan Agency for Medical Research and Development (AMED), Kyoto University Graduate
School of Medicine, Kyoto 606-8501, Japan.
Correspondence to: Dr. Tomohiro Aoki, Center for Innovation in Immunoregulation Technology and Therapeutics (AK project), Kyoto University
Graduate School of Medicine, Konoe-cho Yoshida, Sakyo-ku, Kyoto City, Kyoto 606-8501, Japan. E-mail: tomoaoki@kuhp.kyoto-u.ac.jp
How to cite this article: Koseki H, Aoki T. Population of inflammatory cells in intracranial aneurysm with the special insight to the development of
novel diagnostic and therapeutic approaches. Neuroimmunol Neuroinflammation 2016;3:173-9.

With the background of neurosurgeon, molecular biologist and pharmacologist, Dr. Tomohiro Aoki’s research aims
to develop novel therapeutic drugs to treat intracranial aneurysms or novel diagnostic modalities. He desires to
collaborate with both clinicians and basic researchers to proceed researches.

ABSTRACT

Article history: Intracranial aneurysms (IAs) can cause a lethal subarachnoid hemorrhage after rupture. The
Received: 19-01-2016 prevalence of IA is high in the general public; however, the annual risk for the rupture of
Accepted: 08-07-2016 an incidentally found lesion is relatively low. Therefore, it is crucial to selectively diagnose
Published: 31-08-2016 rupture-prone IAs among many diagnosed IAs, and properly treat such IAs before rupture.
Recent studies using human IA specimens or experimentally-induced IAs in animals have
Key words: revealed some important findings regarding the role of inflammatory cells infiltrating IA
Intracranial aneurysm lesions. Currently, IA is considered an inflammatory disease of the intracranial arterial walls.
macrophage Macrophages are presumably a major type of inflammatory cells regulating the pathogenesis
of IAs through the production of a wide range of pro-inflammatory factors. Based on a series of
neutrophil
mast cell studies, macrophages could be a diagnostic target for rupture-prone IAs. Currently, the potential
diagnostic method to detect iron-engulfing macrophages in IA lesions by magnetic resonance
imaging
imaging is reported. In this review, the authors will summarize the findings regarding the
inflammatory cell types present in IA lesions and discuss future prospects for the development
of a novel diagnostic method identifying rupture-prone IAs.

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