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48.  Lahat N, Shapiro S, Froom P, Kristal‑Boneh E, Inspector M, Miller A.   extracellular signal‑regulated kinase pathway in human vascular
              Inorganic lead enhances cytokine‑induced elevation of matrix   endothelial cells. Brain Res 2012;1455:19‑27.
              metalloproteinase MMP‑9 expression in glial cells. J Neuroimmunol   70.  Wang Q, Luo W, Zheng W, Liu Y, Xu H, Zheng G, Dai Z, Zhang W,
              2002;132:123‑8.                                     Chen Y, Chen J. Iron supplement prevents lead‑induced disruption
           49.  Sansar W, Ahboucha S, Gamrani H. Chronic lead intoxication affects   of the blood‑brain barrier during rat development. Toxicol Appl
              glial and neural systems and induces hypoactivity in adult rat. Acta   Pharmacol 2007;219:33‑41.
              Histochem 2011;113:601‑7.                       71.  Gu H, Wei X, Monnot AD, Fontanilla CV, Behl M, Farlow MR,
           50.  Little AR, O’Callagha JP. Astrogliosis in the adult and developing   Zheng W, Du Y. Lead exposure increases levels of β‑amyloid in
              CNS: is there a role for proinflammatory cytokines? Neurotoxicology   the brain and CSF and inhibits LRP1 expression in APP transgenic
              2001;22:607‑18.                                     mice. Neurosci Lett 2011;490:16‑20.
           51.  Lindahl  LS, Bird  L, Legare  ME, Mikeska  G, Bratton  GR,   72.  Stewart WF, Schwartz BS, Davatzikos C, Shen D, Liu D, Wu X,
              Tiffany‑Castiglioni E. Differential ability of astroglia and neuronal   Todd AC, Shi W, Bassett S, Youssem D. Past adult lead exposure
              cells to accumulate lead: dependence on cell type and on degree   is linked to neurodegeneration measured by brain MRI. Neurology
              of differentiation. Toxicol Sci 1999;50:236‑43.     2006;66:1476‑84.
           52.  Tiffany‑Castiglioni E, Sierra EM, Wu JN, Rowles TK. Lead toxicity   73.  Liu JS, John GR, Sikora A, Lee SC, Brosnan CF. Modulation
              in neuroglia. Neurotoxicology 1989;10:417‑43.       of interleukin‑1beta and tumor necrosis factor alpha signaling
           53.  Legare ME, Barhoumi R, Hebert E, Bratton GR, Burghardt RC,   by P2 purinergic receptors in human fetal astrocytes. J Neurosci
              Tiffany‑Castiglioni E. Analysis of Pb2+ entry into cultured astroglia.   2000;20:5292‑9.
              Toxicol Sci 1998;46:90‑100.                     74.  Gavillet M, Allaman I, Magistretti PJ. Modulation of astrocytic metabolic
           54.  Gahtan E, Overmier JB. Inflammatory pathogenesis in Alzheimer’s   phenotype by proinflammatory cytokines. Glia 2008;56:975‑89.
              disease: biological mechanisms and cognitive sequeli. Neurosci   75.  Huber  JD, Witt  KA, Hom  S, Egleton  RD, Mark  KS, Davis  TP.
              Biobehav Rev 1999;23:615‑33.                        Inflammatory pain alters blood‑brain barrier permeability and
           55.  Ii  M, Sunamoto  M, Ohnishi  K, Ichimori  Y. Beta‑amyloid   tight junctional protein expression. Am J Physiol Heart Circ Physiol
              protein‑dependent nitric oxide production from microglial cells and   2001;280:H1241‑8.
              neurotoxicity. Brain Res 1996;720:93‑100.       76.  O’Shea  RD. Roles and regulation of glutamate transporters
           56.  McCann MJ, O’Callaghan JP, Martin PM, Bertram T, Streit WJ.   in  the  central  nervous  system.  Clin  Exp  Pharmacol  Physiol
              Differential activation of microglia and astrocytes following trimethyl   2002;29:1018‑23.
              tin‑induced neurodegeneration. Neuroscience 1996;72:273‑81.  77.  Biber  K, Vinet  J, Boddeke  HW. Neuron‑microglia signaling:
           57.  Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB,   chemokines as versatile messengers.  J  Neuroimmunol
              Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN,   2008;198:69‑74.
              Hu G, Zhou JW. Suppression of neuroinflammation by astrocytic   78.  Shih  AY, Johnson  DA, Wong  G, Kraft  AD, Jiang  L, Erb  H,
              dopamine D2 receptors via aB‑crystallin. Nature 2013;494:90‑4.  Johnson JA, Murphy TH. Coordinate regulation of glutathione
           58.  Hu S, Sheng WS, Ehrlich LC, Peterson PK, Chao CC. Cytokine effects   biosynthesis and release by Nrf2‑expressing glia potently protects
              on glutamate uptake by human astrocytes. Neuroimmunomodulation   neurons from oxidative stress. J Neurosci 2003;23:3394‑406.
              2000;7:153‑9.                                   79.  Bak  LK, Schousboe  A, Waagepetersen  HS. The glutamate/
           59.  Thornton  P, Pinteaux  E, Gibson  RM, Allan  SM, Rothwell  NJ.   GABA‑glutamine cycle: aspects of transport, neurotransmitter
              Interleukin‑1‑induced neurotoxicity is mediated by glia and   homeostasis and ammonia transfer. J Neurochem 2006;98:641‑53.
              requires caspase activation and free radical release. J Neurochem   80.  McKenna MC. The glutamate‑glutamine cycle is not stoichiometric:
              2006;98:258‑66.                                     fates of glutamate in brain. J Neurosci Res 2007;85:3347‑58.
           60.  Boutin H, LeFeuvre RA, Horai R, Asano M, Iwakura Y, Rothwell NJ.   81.  Pun  PB, Lu  J, Moochhala  S. Involvement of ROS in BBB
              Role of IL‑1alpha and IL‑1beta in ischemic brain damage. J Neurosci   dysfunction. Free Radic Res 2009;43:348‑64.
              2001;21:5528‑34.                                82.  Trotti  D, Nussberger  S, Volterra  A, Hediger  MA. Differential
           61.  da Cunha A, Jefferson JA, Jackson RW, Vitkovic L. Glial cell‑specific   modulation of the uptake currents by redox interconversion of
              mechanisms of TGF‑beta 1 induction by IL‑1 in cerebral cortex.   cysteine residues in the human neuronal glutamate transporter
              J Neuroimmunol 1993;42:71‑85.                       EAAC1. Eur J Neurosci 1997;9:2207‑12.
           62.  Herrera‑Molina R, von Bernhardi R. Transforming growth factor‑beta   83.  Nehru B, Kanwar SS. N‑acetylcysteine exposure on lead‑induced
              1 produced by hippocampal cells modulates microglial reactivity in   lipid peroxidative damage and oxidative defense system in brain
              culture. Neurobiol Dis 2005;19:229‑36.              regions of rats. Biol Trace Elem Res 2004;101:257‑64.
           63.  Cardoso FL, Brites D, Brito MA. Looking at the blood‑brain barrier:   84.  Xu SZ, Shan CJ, Bullock L, Baker L, Rajanna B. Pb2+reduces
              molecular anatomy and possible investigation approaches. Brain   PKCs and NF‑kappaB in vitro. Cell Biol Toxicol 2006;22:189‑98.
              Res Rev 2010;64:328‑63.
           64.  Kim JH, Byun HM, Chung EC, Chung HY, Bae ON. Loss of integrity:   85.  Guo  F, Lou  Y, Feng  N, Li  G, Xie  A, Huang  X, Wang  Y.
                                                                  Exposure to lanthanum compound diminishes LPS‑induced
              impairment of the blood‑brain barrier in heavy metal‑associated
              ischemic stroke. Toxicol Res 2013;29:157‑64.        inflammation‑associated gene expression: involvements of PKC
           65.  Balbuena P, Li W, Ehrich M. Assessments of tight junction proteins   and NF‑kappaB signaling pathways. Biometals 2010;23:669‑80.
              occludin, claudin 5 and scaffold proteins ZO1 and ZO2 in endothelial   86.  Nava‑Ruíz C, Alcaraz‑Zubeldia M, Méndez‑Armenta M, Vergara P,
                                                                  Díaz‑Ruìz A, Ríos C. Nitric oxide synthase immunolocalization and
              cells of the rat blood‑brain barrier: cellular responses to neurotoxicants
              malathion and lead acetate. Neurotoxicology 2011;32:58‑67.  expression in the rat hippocampus after sub‑acute lead acetate
           66.  Shi LZ, Zheng W. Early lead exposure increases the leakage of   exposure in rats. Exp Toxicol Pathol 2010;62:311‑6.
              the blood‑cerebrospinal fluid barrier, in vitro. Hum Exp Toxicol
              2007;26:159‑67.
           67.  I Bannon D, Portnoy ME, Olivi L, Lees PS, Culotta VC, Bressler JP.   Cite this article as: Liu JT, Dong MH, Zhang JQ, Bai Y, Kuang F, Chen LW.
              Uptake of lead and iron by divalent metal transporter 1 in yeast and   Microglia and astroglia: the role of neuroinflammation in lead toxicity and
              mammalian cells. Biochem Biophys Res Commun 2002;295:978‑84.  neuronal injury in the brain. Neuroimmunol Neuroinflammation 2015;2(3):131-7.
           68.  Wang J, Wu J, Zhang Z. Oxidative stress in mouse brain exposed   Source of Support: The National Basic Research Program (2012CB525002,
              to lead. Ann Occup Hyg 2006;50:405‑9.            2011CB504103)  and  National  Natural  Science  Foundation  of  China
           69.  Wang  Q, Lin  Y, Zhang  W, Liu  M, Chen  Y, Chen  J, Luo  W.   (81272346, 31371374). Conflict of Interest: No.
              Lead induces dysregulation of iron regulatory protein 1 via the   Received: 31-08-2014; Accepted: 20-02-2015





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