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Table 5: Early CB and prognosis of 140 severe GBS cases  helpful  in  classifying  the  severity  of  the  illness. [14]
           Prognosis       With CB      Without CB     Total  Electrophysiology  recheck  can  be  very  meaningful
           Good prognosis     46            54         100    to reveal change of patient’s condition, classification
           Poor prognosis     15            25          40    alteration and severity of the nerve damage in time.
           Total              61            79         140
           χ = 0.840, P = 0.360. CB: conduction block; GBS: Gillan‑Barre syndrome
           2
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           Table 6: CB and prognosis of 47 slight GBS cases   1.   Dang JX. Electromyography Diagnosis and Clinical Applications.
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           Good prognosis     7             39          46    2.   Cui LY. Electromyography Condensed Handbook. Beijing: science
           Poor prognosis     0             1           1         Press; 2008.
           Total              7             40          47    3.   Zhang KL, Xu JG. Clinical Utility of Electromyography Diagnosis
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           Patients in this group with CB in early stage were not   anti-glycolipid antibodies. Brain 1995;118:597-605.
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                                                                  Kokubun  N, Nishibayashi  M, Uncini  A, Odaka  M, Hirata  K,
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           Due to the objective condition limit that our patients   the acute “axonal” form of Guillain-Barre syndrome. Muscle Nerve
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           are discharged from our hospital. We have to perform   2002;50:408-16.
           telephone follow-up for most of them. At the same time,   14.  Tang XF. Current insights into nerve block. Chin J Neuo 2003;36:404.
           many patients filled temporary numbers in the contact   15.  Kokubun N, Shahrizaila N, Hirata K, Yuki N. Conduction block
                                                                  and axonal degeneration co-occurring in a patient with axonal
           information form when hospitalized, which were no      Guillain-Barré syndrome. J Neurol Sci 2012;319:164-7.
           longer used after they went back. This also limited the   16.  Raguer N, Gratacós M, Lladó E, Lara N, Seoane JL, Benito M, Rio J,
           follow-up results, and the response rate was only 65%.   Gámez J. Acute motor axonal neuropathy (AMAN), description of
           Furthermore, through telephone follow-up, we can’t     neurophysiological findings in 8 patients with early nerve conduction
                                                                  blocks. Clin Neurophysiol 2006;117:1-2.
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           In conclusion, reversible CB might be the cause of     J Brain Nerv Dis 2006;14:239.
           changes in patients’ electro-physiological classification.
           CB is not only a typical electro-physiological
           manifestation in AIDP, but also a manifestation of
           axonal degeneration for AMAN in the early stage.    Cite this article as: Wang YC, Feng GD, Wang J, Liu XD, Zhao G. Effect of
                                                               conduction block in classification and prognosis of Guillain-Barre syndrome.
           CB and axonal degeneration are caused by immune-    Neuroimmunol Neuroinflammation 2014;1(2):77-81.
           mediated damage factors which attack axon membrane   Source of Support: Nil. Conflict of Interest: No.
           on the motor fiber. To a certain extent, CB is very   Received: 12-05-2014; Accepted: 18-07-2014






          Neuroimmunol Neuroinflammation | Volume 1 | Issue 2 | September 2014                              81
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