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Page 10 of 19                                                                                          Son et al. Microbiome Res Rep. 2025;4:29      https://dx.doi.org/10.20517/mrr.2025.14



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                          Table 3. Changes in RA of jejunal mucosa-associated microbiota in nursery pigs challenged with F18  E. coli
                                          Inoculation      Inoculation     Days post                                                                 Response  1
                          Ref.
                                          BW (kg)          age (d)         inoculation (d)     Phylum         Family                                               Genus                Species

                          Duarte and      NA               28              21                  No effect        Helicobacteraceae ↑ Pseudomonadaceae ↑               Helicobacter ↑     Helicobacter rappini ↑ Helicobacter
                              [23]                                                                                                                                                               #
                          Kim                                                                                   Xanthomonadaceae ↑ Peptostreptococcaceae ↑           Campylobacter ↓    equorum ↑
                                                                                                                                                                                                                  #
                                                                                                                Campylobacteraceae ↓ Enterobacteriaceae ↓                               Streptococcus hyointestinalis ↑
                                                                                                                Brachyspiraceae ↓ Caulobacteraceae ↓                                    Campylobacter coli ↓ Acinetobacter
                                                                                                                                                                                        lwoffii ↓
                                                                                                                                                                                 #
                          Garavito-Duarte  6.3             28              21                  Bacteroidetes ↑   Prevotellaceae ↑ Lachnospiraceae ↑                  Lactobacillus ↓    Helicobacter equorum ↑
                              [27]                                                                          #                                     #                                #
                          et al.                                                               Spirochaetae ↑   Ruminococcaceae ↑ Lactobacillaceae ↓                 Bifidobacterium ↓  Bifidobacterium dentium ↓
                                                                                                                                  #
                                                                                                                Bifidobacteriaceae ↓                                                    Lactobacillus delbrueckii ↓
                                                                                                                                                                                        Bifidobacterium boum ↓
                                                                                                                                                                                        Lactobacillus salivarius ↓
                                      [28]
                          Gormley et al.  6.4              28              21                  -                -                                                    Bradyrhizobium ↑   -
                                                                                                                                                                     Eubacterium ↑
                                                                                                                                                                     Romboutsia ↑
                                                                                                                                                                     Selenomonas ↑

                                                                                                                                                                     Terrisporobacter ↑
                                                                                                                                                                     Prevotella ↑
                                                                                                                                                                     Solobacterium ↓
                                                                                                                                                                     Bacillus ↓
                                                                                                                                                                     Corynebacterium ↓
                                     [9]                                                                    #                       #
                          Duarte et al.   6.9              28              21                  Bacteroidetes ↓  Acidaminococcaceae ↓                                 -                  Prevotella stercorea ↓
                                                                                                                                                                                        Phascolarctobacterium
                                                                                                                                                                                                     #
                                                                                                                                                                                        succinatutens ↓
                                                                                                                                                                                                              #
                                                                                                                                                                                        Lactobacillus delbrueckii ↓
                                                                                                                                                                                                      #
                                                                                                                                                                                        Prevotella copri ↓
                                   [29]
                          Jang et al.     7.2              28              21                  No effect        No effect                                            -                  -
                                 [30]                                                                                               #
                          Xu et al.       7.1              28              21                  No effect        Campylobacteraceae ↓                                 Selenomonas ↓      Helicobacter rodentium ↑
                                     [36]                                                                                         #               #                              #                    #
                          Duarte et al.   8.2              28              13                  Proteobacteria ↑   Helicobacteraceae ↑  Prevotellaceae ↓              Helicobacter ↑     Prevotella copri ↓
                                                                                                                               #              #
                                                                                               Bacteroidetes ↓   Veillonellaceae ↓  Clostridiaceae ↓                 Mitsuokella ↓      Selenomonas bovis ↓
                                                                                               Firmicutes ↓                                                          Selenomonas ↓      Roseburia faecis ↓
                                                                                                                                                                     Megasphaera ↓      Selenomonas lipolytica ↓
                                                                                                                                                                                        Acidaminococcus fermentans ↓
                                     [37]
                          Duarte et al.   8.2              NA              21                  Proteobacteria ↑  Helicobacteraceae ↑ Prevotellaceae ↓ Lactobacillaceae ↓   -            Helicobacter mastomyrinus ↑
                                                                                                                                #                     #
                                                                                               Bacteroidetes ↓  Lachnospiraceae ↓  Campylobacteraceae ↓                                 Prevotella copri ↓
                                                                                               Firmicutes ↓                                                                             Prevotella stercorea ↓ Roseburia
                                                                                                                                                                                        faecis ↓

                          1
                          All results represent statistically significant changes (P < 0.05) in the positive control (E. coli-challenged group) relative to the negative control (non-challenged group), except for those marked with a hash (#),
                          which indicate a statistical tendency (P < 0.10). RA: Relative abundance; E. coli: Escherichia coli; BW: body weight; NA: not available.
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